Cancer cells assemble and align gold nanorods conjugated to antibodies to produce highly enhanced, sharp, and polarized surface Raman spectra: A potential cancer diagnostic marker
Cancer cells assemble and align gold nanorods conjugated to antibodies to produce highly enhanced, sharp, and polarized surface Raman spectra: A potential cancer diagnostic marker
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DOI：
10.1021/nl070472c
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发表时间：
2007-06-01
期刊：
影响因子：
10.8
通讯作者：
El-Sayed, Mostafa A.
中科院分区：
文献类型：
--
作者：
Huang, Xiaohua;El-Sayed, Ivan H.;El-Sayed, Mostafa A.
人类口腔癌细胞被发现组装和排列金纳米棒共轭抗表皮生长因子受体（抗EGFR）抗体。之前已证明免疫缀合的金纳米棒和纳米球表现出对成像有用的强Rayleigh（Mie）散射。在这封信中，发现癌细胞上纳米棒附近的分子给出了大大增强的拉曼光谱（由于纳米棒组件的高表面等离子体场，其中它们的扩展表面等离子体场重叠），尖锐的（由于均匀的环境）和偏振的（由于各向异性排列）。这些观察到的特性可用作癌细胞的诊断特征。
Human oral cancer cells are found to assemble and align gold nanorods conjugated to anti-epidermal growth factor receptor (anti-EGFR) antibodies. Immnoconjugated gold nanorods and nanospheres were shown previously to exhibit strong Rayleigh (Mie) scattering useful for imaging. In the present letter, molecules near the nanorods on the cancer cells are found to give a Raman spectrum that is greatly enhanced (due to the high surface plasmon field of the nanorod assembly in which their extended surface plasmon fields overlap), sharp (due to a homogeneous environment), and polarized (due to anisotropic alignments). These observed properties can be used as diagnostic signatures for cancer cells.