Chiral Diphosphine-Palladium-Catalyzed Sequential Asymmetric Double-Friedel-Crafts Alkylation and N-Hemiketalization for Spiro-polycyclic Indole Derivatives.
Chiral Diphosphine-Palladium-Catalyzed Sequential Asymmetric Double-Friedel-Crafts Alkylation and N-Hemiketalization for Spiro-polycyclic Indole Derivatives.
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DOI：
10.1021/acs.orglett.7b00368
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发表时间：
2017-04
期刊：
影响因子：
5.2
通讯作者：
Naiying Li;Junqi Zhang;Bingbing Sun;Hai-yan Li;Xing-Wang Wang-Xing-Wang-Wang-2426252
中科院分区：
文献类型：
--
作者：
Naiying Li;Junqi Zhang;Bingbing Sun;Hai-yan Li;Xing-Wang Wang-Xing-Wang-Wang-2426252
在手性二膦-钯（II）催化剂的作用下，3-烷基吲哚与β，γ-不饱和α-酮酯进行了高效的级联不对称Friedel-Crafts烷基化/ n -半池化/Friedel-Crafts烷基化反应。一系列对映体富集的螺环多环吲哚衍生物具有优异的对映选择性和非对映选择性。
An efficient cascade asymmetric Friedel-Crafts alkylation/N-hemiketalization/Friedel-Crafts alkylation reaction of 3-alkylindoles with oxindolyl β,γ-unsaturated α-ketoesters has been developed in the presence of a chiral diphosphine-palladium(II) catalyst. A series of enantiomerically enriched spiro-polycyclic indole derivatives have been constructed in high yields with excellent enantioselectivities and diastereoselectivities.