Antagonism of the cytotoxic but not antiviral effects of ara-sangivamycin by adenosine.
Antagonism of the cytotoxic but not antiviral effects of ara-sangivamycin by adenosine.
复制标题
腺苷拮抗阿拉-桑吉瓦霉素的细胞毒性作用，但不拮抗抗病毒作用。
DOI：
10.1128/aac.33.9.1606
复制
发表时间：
1989
影响因子：
4.9
通讯作者：
Drach,JC
中科院分区：
文献类型：
--
作者：
Birch,GM;Krawczyk,SH;Townsend,LB;Drach,JC
阿桑霉素对DNA合成的抑制作用可被腺苷拮抗。在1.0至50 μ M腺苷存在下，50%抑制浓度分别增加1.6至32倍。与此相反，阿糖胞苷对人巨细胞病毒复制的抑制作用不被50 μ M腺苷拮抗。这表明不同的酶负责未感染和感染细胞中阿糖胞苷-桑吉瓦霉素的磷酸化。
Inhibition of DNA synthesis by ara-sangivamycin was antagonized by adenosine. The 50% inhibitory concentrations increased 1.6- to 32-fold in the presence of 1.0 to 50 microM adenosine, respectively. In contrast, the inhibition of human cytomegalovirus replication by ara-sangivamycin was not antagonized by as much as 50 microM adenosine. This suggests that different enzymes were responsible for the phosphorylation of ara-sangivamycin in uninfected and infected cells.