In vitro and in vivo corrosion and histocompatibility of pure Mg and a Mg-6Zn alloy as urinary implants in rat model
In vitro and in vivo corrosion and histocompatibility of pure Mg and a Mg-6Zn alloy as urinary implants in rat model
复制标题
纯镁和 Mg-6Zn 合金作为大鼠尿路植入物的体外和体内腐蚀及组织相容性
DOI：
10.1016/j.msec.2016.06.017
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Li Yan
中科院分区：
文献类型：
--
作者：
Zhang Shiying;Zheng Yang;Zhang Liming;Bi Yanze;Li Jianye;Liu Jiao;Yu Youbin;Guo Heqing;Li Yan
纯Mg和Mg-6重量%锌合金被认为是泌尿系统可降解植入物的潜在候选者。通过动电位极化曲线和37 °C模拟体液（SBF）浸泡试验，研究了其在体外的腐蚀行为。通过植入Wistar大鼠膀胱内，检测其体内降解和组织相容性。合金元素Zn提高了钝化电位，增加了阴极电流密度.体外和体内降解试验均表明Mg-6 Zn合金的腐蚀速率更快。HE染色结果显示，Mg-6 Zn合金与纯Mg合金在膀胱内均表现出良好的组织相容性，两组间膀胱、肝、肾组织在2周内无明显差异。总之，这项工作提供了有益的信息，纯镁和镁-6锌合金在泌尿系统中的降解性能和组织相容性。
Pure Mg and a Mg-6 wt.% Zn alloy were investigated as potential candidates for biodegradable implants for the urinary system. The in vitro corrosion behavior was studied by potentiodynamic polarization and immersion tests in simulated body fluid (SBF) at 37 °C. The in vivo degradation and histocompatibility were examined through implantation into the bladders of Wistar rats. The alloying element Zn elevated the passivation potential and increased the cathodic current density. Both in vitro and in vivo degradation tests showed a faster corrosion rate for the Mg-6Zn alloy. Tissues stained with hematoxylin and eosin (HE) suggested that both pure Mg and Mg-6Zn alloy exhibited good histocompatibility in the bladder indwelling implantation and no differences between pure Mg and Mg-6Zn groups were found in bladder, liver and kidney tissues during the 2 weeks implantation. Overall, this work presented instructive information on the degradation properties and histocompatibility of pure Mg and the Mg-6Zn alloy in the urinary system.