Antigenic hybrids of influenza A viruses with surface antigens to order.
Antigenic hybrids of influenza A viruses with surface antigens to order.
复制标题
甲型流感病毒与表面抗原的抗原杂交体可供订购。
DOI：
10.1016/0042-6822(70)90309-0
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发表时间：
1970
期刊：
影响因子：
3.7
通讯作者：
R. G. Webster
中科院分区：
文献类型：
--
作者：
R. G. Webster;R. G. Webster
甲型流感病毒的哺乳动物和禽类毒株之间的稳定抗原杂交体具有来自一个亲本的血凝素和来自另一亲本的神经氨酸酶抗原，可以在尿囊壳系统中定制。通过使用针对亲本病毒的血凝素和神经氨酸酶抗原的特异性抗血清，使它们的分离成为可能。讨论了抗原杂交对大流行毒株起源的影响以及实验室杂交在流感抗原变异研究中的应用。
Stable antigenic hybrids between mammalian and avian strains of influenza A viruses with the hemagglutinin from one parent and the neuraminidase antigen from the other parent can be made to order in the allantois-on-shell system. Their isolation was made possible by the use of specific antisera to the hemagglutinin and neuraminidase antigens of the parental viruses. The implications of antigenic hybrids in the origin of pandemic strains and the uses of laboratory hybrids in the study of antigenic variation in influenza are discussed.