Elastically coupled two-level systems as a model for biopolymer extensibility
Elastically coupled two-level systems as a model for biopolymer extensibility
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DOI：
10.1103/physrevlett.81.4764
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发表时间：
1998-11-23
影响因子：
8.6
通讯作者：
Gaub, HE
中科院分区：
文献类型：
--
作者：
Rief, M;Fernandez, JM;Gaub, HE
我们对由链段组成的生物聚合物的弹性进行了蒙特卡罗模拟，这些链段可以经历构象转变。基于弹性耦合二能级系统的热力学，计算了每一段的跃迁几率和相应的长度变化。对于构象变化快的葡聚糖和肌肉蛋白Titin，该模型的描述与测量数据都得到了很好的吻合，其中过渡力的显着速率依赖关系可以用非平衡过程来解释。[S0031-9007(98)07735-7]。
We present Monte Carlo simulations for the elasticity of biopolymers consisting of segments that can undergo conformational transitions. Based on the thermodynamics of an elastically coupled two level system, the probability For a transition and a related change in length of each segment was calculated. Good agreement between this model description and measured data was found for both the polysaccharide dextran where the conformational changes are fast and the muscle protein titin where the marked rate dependence of the transition forces could be explained by nonequilibrium processes. [S0031-9007(98)07735-7].