Increased serum chemerin concentrations in patients with polycystic ovary syndrome: Relationship between insulin resistance and ovarian volume
Increased serum chemerin concentrations in patients with polycystic ovary syndrome: Relationship between insulin resistance and ovarian volume
复制标题
多囊卵巢综合征患者血清凯莫瑞浓度升高：胰岛素抵抗与卵巢体积之间的关系
DOI：
10.1016/j.cca.2015.09.015
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发表时间：
2015-10-23
影响因子：
5
通讯作者：
Liu, Wei
中科院分区：
文献类型：
--
作者：
Huang, Rong;Yue, Jiang;Liu, Wei
背景：Chemerin 与肥胖和胰岛素抵抗 (IR) 有关，而肥胖和胰岛素抵抗 (IR) 是多囊卵巢综合征 (PCOS) 的共同特征。 Chemerin 还显示出对卵泡类固醇生成的抑制作用。我们调查了 PCOS 患者凯莫林与 IR 或多囊卵巢形态之间的关联。方法：共有 148 名采用鹿特丹标准新诊断 PCOS 的女性和 88 名健康个体入组。招募的 PCOS 患者按照血清凯莫瑞浓度三分位数进一步分层，如下：第一组 (30.27 ng/ml)。 结果：与对照组相比，每个三分位数的 PCOS 女性具有更高的血清凯莫瑞浓度。通过线性回归分析，在调整混杂因素后，稳态模型评估-胰岛素抵抗和卵巢体积显示与凯莫瑞显着相关（分别为β = 0.257，P = 0.028；β = 0.276，P = 0.005）。 The odds ratios (ORs) for ovarian volume excess gradually increased across increasing tertiles of chemerin in the adjusted model [Group 1: reference;第 2 组：OR 1.602； 95%置信区间（Cl）：1.170-2.194；第 3 组：OR 1.857； 95% Cl：1.335-2.583]。结论：与健康女性相比，PCOS 患者的血清凯莫瑞浓度升高。无论肥胖与否，凯莫瑞水平较高的个人在 PCOS 患者中往往具有较高的卵巢体积过剩风险。 (C) 2015 Elsevier B.V. 保留所有权利。
Background: Chemerin has been linked to adiposity, and insulin resistance (IR) which are the common characteristics of polycystic ovary syndrome (PCOS). Chemerin also shows inhibitory action on follicular steroidogenesis. We investigated the associations between chemerin and IR or polycystic ovary morphology in patients with PCOS.Methods: A total of 148 women with newly diagnosed PCOS using Rotterdam criteria and 88 healthy individuals were enrolled. The recruited patients with PCOS were further stratified by tertiles of serum chemerin concentrations as follows: Group I (30.27 ng/ml).Results: Compared to controls, women with PCOS in each tertile had higher serum chemerin concentrations. By linear regression analysis, homeostasis model assessment-insulin resistance and ovarian volume showed significant associations with chemerin after adjusting for confounding factors (beta = 0.257, P = 0.028; beta = 0.276, P = 0.005, respectively). The odds ratios (ORs) for ovarian volume excess gradually increased across increasing tertiles of chemerin in the adjusted model [Group 1: reference; Group 2: OR 1.602; 95% confidence interval (Cl): 1.170-2.194; Group 3: OR 1.857; 95% Cl: 1.335-2.583].Conclusions: Patients with PCOS showed increased serum chemerin concentrations as compared to healthy women. Individuals with higher chemerin tended to have higher risk for ovarian volume excess in patients with PCOS, regardless of adiposity. (C) 2015 Elsevier B.V. All rights reserved.