Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry
Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry
复制标题
使用实时质谱直接分析快速筛查草药膳食补充剂中的合成抗糖尿病药物掺假
DOI：
10.1039/c0an01047b
复制
发表时间：
2011-01-01
期刊：
影响因子：
4.2
通讯作者：
Liu, Huwei
中科院分区：
文献类型：
--
作者：
Zhou, Zhigui;Zhang, Jialing;Liu, Huwei
在草药补充剂中掺入合成药物是非法的。建立了一种快速、可靠的直接分析实时质谱仪(DART-MS)检测草药膳食补充剂中7种人工合成抗糖尿病药物的方法。补充样品用甲醇/水提取，经多次手动振荡后直接用DART-MS分析。通过四重飞行时间质谱仪(QTOF MS)获得准确的m/z值和MS/MS数据，证实了合成药物掺假的存在。系统地优化了DART源的参数，并测量了草药补充剂基质中的检出限(LOD)。该方法被成功地应用于五种商品草药膳食补充剂的检测，其中两种被证明在没有标签的情况下掺入了二甲双胍。
Adulteration of herbal supplements with synthetic drugs is illegal. A rapid and reliable method which utilizes direct analysis in real time mass spectrometry (DART-MS) was developed for the identification of seven synthetic antidiabetic drugs used as adulterants in herbal dietary supplements. The supplement sample was simply extracted with methanol/water by manually shaking several times and directly analyzed using DART-MS. The presence of synthetic drug adulterants was confirmed through the accurate m/z values and MS/MS data obtained via quadruple time of flight mass spectrometry (QTOF MS). Parameters for the DART source were systematically optimized, and the limits of detection (LODs) in herbal supplement matrices were measured. This method was successfully applied to examine five commercial herbal dietary supplements, and two of them proved to be adulterated with metformin without labeling.