Wang Linker Free of Side Reactions
Wang Linker Free of Side Reactions
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DOI：
10.1021/ol303367s
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发表时间：
2013-01-18
期刊：
影响因子：
5.2
通讯作者：
Albericio, Fernando
中科院分区：
文献类型：
--
作者：
Castro, Vida;Rodriguez, Hortensia;Albericio, Fernando
研制了一种用于肽酸固相合成的新型树脂。它基于具有两个独特特征的连接剂：甲氧基是苯基环的唯一激活基团，铜(I)催化的Click化学反应将其锚定在固体载体上。并与王氏树脂进行了固相多肽合成效率的比较。
A new resin for the solid-phase synthesis of peptide acids was developed. It was based on a linker with two unique features: methoxy groups as the only activating groups of the phenyl ring and a copper(I)-catalyzed Click chemistry reaction to anchor it to the solid support. The efficiency of this new resin in solid phase peptide synthesis was compared with that of Wang resin.