Introduction to the special issue on adverse outcome pathways in radiation protection
Introduction to the special issue on adverse outcome pathways in radiation protection
复制标题
辐射防护不良后果途径特刊介绍
DOI：
10.1080/09553002.2022.2123183
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发表时间：
2022
影响因子：
2.6
通讯作者：
N. Hamada
中科院分区：
文献类型：
--
作者：
V. Chauhan;O. Azimzadeh;S. Salomaa;N. Hamada
《国际辐射生物学杂志》的这期特刊题为“辐射防护中的不良后果途径”，其灵感来自于全球对综合辐射生物学和流行病学信息以提高对低剂量辐射健康风险评估的科学认识的日益增长的兴趣。不良后果途径（AOP）是一个概念框架，其特征是与生物组织不同层次上的一系列因果联系的关键事件相关的应激源，从分子起始事件开始，最终导致不良健康后果。该特刊提供了一个全面的概述AOPs，起源的摘要，一个新成立的专题组的目标，目前的案例AOPs和辐射领域如何利用AOPs结构的辐射照射的生物效应的现有知识。特刊包括一个评论（Chauhan，Beaton等人，2022），四篇综述（Azimzadeh等人，2022; Chauhan，Hamada，Wilkins等人，2022; Chauhan，Hamada，Garnier-Laplace等人，2022; Jaylet等人，2022）和7篇研究文章（Adam等人，2022; Burtt等人，2022; Klokov等人，2022; Kozbenko等人，2022; Kozbenko等人，2022; Tollefsen等人，2022; Yu等人，2022年）据设想，高级氧化物可能有助于更好地描绘和定义早期的机械变化和辐射事件的序列与公众和生态系统保护相关的健康结果有因果关系的暴露。然后，为AOP提供信息的数据可用于设计与监管决策相关的稳健的生物测定和风险模型策略。然而，在实现这一目标之前，需要解决一些重要的问题，即不同类型、剂量和剂量率的辐射暴露如何准确地告知AOP的发展，以及AOP如何以简化的形式反映不良健康后果的潜伏期。辐射界提出的这些问题和其他问题只能通过实际的AOP建设以及化学毒理学领域AOP专家的共享经验来解决。
This special issue of the International Journal of Radiation Biology entitled ‘Adverse Outcome Pathways in Radiation Protection’is inspired by growing global interest in approaches for integrating information from radiation biology and epidemiology to improve scientific understanding of low dose radiation health risk assessment. The adverse outcome pathway (AOP) represents a conceptual framework characterizing a stressor associated with a sequential set of causally linked key events at different levels of biological organization, beginning with a molecular initiating event and culminating in an adverse health outcome. The special issue provides a comprehensive overview of AOPs, a summary of origin, the goals of a newly formed topical group, current case examples of AOPs and how the radiation field can harness AOPs to structure the available knowledge on the biological effects of radiation exposure. The special issue consists of a commentary (Chauhan, Beaton, et al. 2022), four reviews (Azimzadeh et al. 2022; Chauhan, Hamada, Wilkins, et al. 2022; Chauhan, Hamada, Garnier-Laplace, et al. 2022; Jaylet et al. 2022) and seven research articles (Adam et al. 2022; Burtt et al. 2022; Klokov et al. 2022; Kozbenko et al. 2022; Stainforth et al. 2022; Tollefsen et al. 2022; Yu et al. 2022).It is envisioned that AOPs could contribute toward better delineating and defining early mechanistic changes and a sequence of events from radiation exposures that are causally linked to health outcomes relevant to public and ecosystem protection. The data informing AOPs could then be used for designing robust bioassays and risk model strategies relevant to regulatory decision-making. However, before this goal is reached, some important questions need to be addressed as to how different types, doses and dose rates of radiation exposure can accurately inform AOP development and how AOPs can reflect the latency of adverse health outcomes in a simplified form. These and other questions posed by the radiation community can only be addressed through practical AOP construction, and through shared experiences from the AOP experts in the chemical toxicology field.