Interleukin-1 and Stroke: Biomarker, Harbinger of Damage, and Therapeutic Target
Interleukin-1 and Stroke: Biomarker, Harbinger of Damage, and Therapeutic Target
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DOI：
10.1159/000332205
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发表时间：
2011-01-01
影响因子：
2.9
通讯作者：
Allan, Stuart M.
中科院分区：
文献类型：
--
作者：
Denes, Adam;Pinteaux, Emmanuel;Allan, Stuart M.
炎症是脑血管疾病的诱因之一。中风的危险因素包括许多与慢性或急性炎症相关的疾病，在实验研究中，脑血管事件后大脑的炎症变化对结果有影响，临床研究的证据越来越多。大脑非常容易受到炎症的攻击，但驻留的神经胶质细胞、内皮细胞和神经元都可以对感染或损伤产生明显的炎症反应。最近的发现强调了外周来源的免疫细胞和炎症分子在各种中枢神经系统疾病（包括中风）中的重要性。炎症细胞因子，白细胞介素-1 (IL-1)，在局部和全身炎症中起关键作用，是感染或损伤的外周和中枢免疫反应的关键驱动因素。抑制IL-1在多种急性脑损伤的实验范式中具有有益的作用，是脑卒中的一个有前景的临床靶点。我们提出，阻断IL-1可能在治疗几种中风危险因素的疾病上有用，并且已经有相当多的临床前和临床证据表明，IL-1受体拮抗剂抑制IL-1可能在急性中风的治疗中有价值。巴塞尔S. Karger股份有限公司版权所有
Inflammation is established as a contributor to cerebrovascular disease. Risk factors for stroke include many conditions associated with chronic or acute inflammation, and inflammatory changes in the brain after cerebrovascular events contribute to outcome in experimental studies, with growing evidence from clinical research. The brain is extremely susceptible to inflammatory challenge, but resident glia, endothelial cells and neurones can all mount a pronounced inflammatory response to infection or injury. Recent discoveries highlight the importance of peripherally-derived immune cells and inflammatory molecules in various central nervous system disorders, including stroke. The inflammatory cytokine, interleukin-1 (IL-1), plays a pivotal role in both local and systemic inflammation, and is a key driver of peripheral and central immune responses to infection or injury. Inhibition of IL-1 has beneficial effects in a variety of experimental paradigms of acute brain injury and is a promising clinical target in stroke. We propose that blockade of IL-1 could be therapeutically useful in several diseases which are risk factors for stroke, and there is already considerable preclinical and clinical evidence that inhibition of IL-1 by IL-1 receptor antagonist may be valuable in the management of acute stroke. Copyright (C) 2011 S. Karger AG, Basel