Interleukin-6 response to exercise during acute and chronic hypoxia
Interleukin-6 response to exercise during acute and chronic hypoxia
复制标题
急性和慢性缺氧期间白介素 6 对运动的反应
DOI：
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发表时间：
2003
影响因子：
3
通讯作者：
A. Steensberg
中科院分区：
文献类型：
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作者：
C. Lundby;A. Steensberg
长期运动与细胞因子白细胞介素-6（IL-6）的血浆水平增加有关。循环中的儿茶酚胺水平和运动强度都与运动产生的IL-6相关。在缺氧和适应期间，交感神经活动发生变化，并且给定的工作负荷在缺氧中变得更加强烈。因此，缺氧提供了一个独特的机会来研究儿茶酚胺和强度对运动源性IL-6的影响。在本研究中，8名丹麦海平面居民在海平面（SL）进行了60分钟的自行车测力计运动。（154 W，45%最大O2消耗量，V~O2max），在急性（AH）和慢性缺氧（CH），在相同的绝对值（abs）（AHabs = 154 W，54% V时O2max; CHabs = 154 W，59% V时O2max）和相同的相对（rel）（AHrel = 130 W，46% V时O2max; CHrel = 120 W，44% V时O2max）工作负荷。我们假设，在相同的绝对工作量的IL-6运动的反应将增加在缺氧期间相比，海平面，这些变化不会与儿茶酚胺的变化。在AHabs（2.35 pg·ml-1）和CHabs（3.34 pg·ml-1）中，与海平面（0.78·ml-1）相比，IL-6对运动的反应增强（p <0.05）。此外，在海平面骑自行车60分钟后，AHrel（1.02 pg·ml-1）和CHrel（1.31 pg·ml-1）导致类似的IL-6反应。当比较所有试验时，AHabs和CHabs期间增强的IL-6应答与循环儿茶酚胺水平的变化不匹配。我们的结论是，血浆IL-6浓度在低氧运动是强度依赖性的，和其他因素比儿茶酚胺水平更重要的调节。
Prolonged exercise is associated with increased plasma levels of the cytokine interleukin-6 (IL-6). Both circulating catecholamine levels and exercise intensity have been related to the exercise-derived IL-6. During hypoxia and acclimatization, changes in sympathetic activity is seen, and also a given workload becomes more intense in hypoxia. Therefore, hypoxia offers a unique opportunity to study the effect of catecholamines and intensity on exercise-derived IL-6. In the present study, eight Danish sea-level residents performed 60 min of cycle ergometer exercise at sea level (SL) (154 W, 45% maximal O2 consumption, V̇O2max), in acute (AH) and chronic hypoxia (CH), at the same absolute (abs) (AHabs=154 W, 54% V̇O2max; CHabs=154 W, 59% V̇O2max) and same relative (rel) (AHrel=130 W, 46% V̇O2max; CHrel=120 W, 44% V̇O2max) workload. We hypothesized that the IL-6 response to exercise at the same absolute workload would be augmented during hypoxia compared with sea level, and that these changes would not correlate with changes in catecholamines. In AHabs (2.35 pg·ml−1) and CHabs (3.34 pg·ml−1) the IL-6 response to exercise was augmented (p<0.05) compared with that at sea level (0.78·ml−1). In addition, after 60 min of bicycling at sea level, AHrel (1.02 pg·ml−1) and CHrel (1.31 pg·ml−1) resulted in similar IL-6 responses. The augmented IL-6 response during AHabs and CHabs did not match changes in circulating catecholamine levels when comparing all trials. We conclude that the plasma IL-6 concentration during exercise in hypoxia is intensity dependent, and that factors other than catecholamine levels are more important for its regulation.