Reinvestigation of an endogenous meiotic drive system in the mosquito, Aedes aegypti (Diptera: Culicidae)
Reinvestigation of an endogenous meiotic drive system in the mosquito, Aedes aegypti (Diptera: Culicidae)
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DOI：
10.1603/0022-2585-41.6.1027
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发表时间：
2004-11-01
影响因子：
2.1
通讯作者：
Severson, DW
中科院分区：
文献类型：
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作者：
Mori, A;Chadee, DD;Severson, DW
我们已开始努力确定埃及伊蚊 M-D 减数分裂驱动系统的分子基础。 M-D 基因的影响是高度男性偏向的性别比例，但根据易感反应者 m(s) 等位基因的频率和敏感性而变化。 M-D 系统有潜力作为驱动天然伊蚊的病原体抗性转基因的机制。埃及伊蚊种群。由于所有先前存在的携带 M-D 基因的实验室菌株均已丢失，因此我们选择了携带强大驱动程序的新菌株 T37。 T37 雄性与易受驱力影响的 m(s) 雌性交配会产生性别比例高度偏差的后代，其中仅产生大约 14.7% 的雌性。我们讨论了基于与充分描述的果蝇分离扭曲（SD）减数分裂驱动系统的比较和转基因 Ae 释放的考虑来识别 M-D 候选基因的潜力。埃及伊蚊进入自然种群，其中 M-D 和不敏感的 m(i) 等位基因可能发生分离。
We have initiated efforts to determine the molecular basis for the M-D meiotic drive system in the mosquito, Aedes aegypti. The effect of the M-D gene is a highly male-biased sex ratio, but varies depending on the frequency and sensitivity of a susceptible responder m(s) allele. The M-D system has potential as a mechanism for driving trangenes for pathogen resistance into natural Ae. aegypti populations. Because all previously existing laboratory strains carrying the M-D gene have been lost, we have selected for a new strain, T37, that carries a strong driver. Matings between T37 males and drive-susceptible in m(s) females result in progeny with highly biased sex ratios, wherein only approximate to14.7% females are produced. We discuss the potential for identifying M-D candidate genes based on comparisons with the well-described Drosophila melanogaster segregation distorter (SD) meiotic drive system and considerations for release of transgenic Ae. aegypti into natural populations where M-D and insensitive m(i) alleles are likely segregating.