INTERLEUKIN-9 AND ITS RECEPTOR - INVOLVEMENT IN MAST-CELL DIFFERENTIATION AND T-CELL ONCOGENESIS
INTERLEUKIN-9 AND ITS RECEPTOR - INVOLVEMENT IN MAST-CELL DIFFERENTIATION AND T-CELL ONCOGENESIS
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DOI：
10.1002/jlb.57.3.353
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发表时间：
1995-03-01
影响因子：
5.5
通讯作者：
VANSNICK, J
中科院分区：
文献类型：
--
作者：
RENAULD, JC;KERMOUNI, A;VANSNICK, J
白细胞介素-9（IL-9）是一种多功能细胞因子，由体外活化的TH 2克隆和体内TH 2样T细胞应答期间产生。IL-9受体是促红细胞生成素受体超家族的成员，并与IL-2受体的γ链相互作用以进行信号转导。各种观察表明IL-9通过诱导肥大细胞的增殖和分化而积极参与肥大细胞应答。IL-9在T细胞应答中的作用尚不清楚。虽然新鲜分离的正常T细胞不响应IL-9，这种细胞因子诱导小鼠T细胞淋巴瘤在体外和体内的IL-9的过度表达的胸腺淋巴瘤的发展结果的增殖。在人类中，IL-9介导的自分泌环的存在已被认为是某些恶性肿瘤如霍奇金病的原因。IL-9的其他潜在生物学靶点包括B淋巴细胞、造血祖细胞和未成熟神经元细胞系。
Interleukin-9 (IL-9) is a multifunctional cytokine produced by activated TH2 clones in vitro and during TH2-like T cell responses in vivo. The IL-9 receptor is a member of the hemopoietin receptor superfamily and interacts with the gamma chain of the IL-2 receptor for signal transduction. Various observations indicate that IL-9 is actively involved in mast cell responses by inducing the proliferation and differentiation of these cells, The role of IL-9 in T cell responses is less clear. Although freshly isolated normal T cells do not respond to IL-9, this cytokine induces the proliferation of murine T cell lymphomas in vitro and in vivo overexpression of IL-9 results in the development of thymic lymphomas. In the human, the existence of an IL-9-mediated autocrine loop has been suggested for some malignancies such as Hodgkin's disease. Other potential biological targets for IL-9 include B lymphocytes, hematopoietic progenitors, and immature neuronal cell lines.