Multipoint genetic mapping with uniparental disomy data.
Multipoint genetic mapping with uniparental disomy data.
复制标题
使用单亲二体数据进行多点遗传作图。
DOI：
10.1086/303072
复制
发表时间：
2000
影响因子：
9.8
通讯作者：
Robinson,WP
中科院分区：
文献类型：
--
作者：
Zhao,H;Li,J;Robinson,WP
Uniparental disomy (UPD) refers to the presence of two copies of a chromosome from one parent and none from the other parent. In genetic studies of UPDs, many genetic markers are usually used to identify the stage of nondisjunction that leads to UPD and to uncover the associated unusual patterns of recombinations. However, genetic information in such data has not been fully utilized because of the limitations of the existing statistical methods for UPD data. In the present article, we develop a multilocus statistical approach that has the advantages of being able to simultaneously consider all genetic markers for all individuals in the same analysis and to allow general models for the crossover process to incorporate crossover interference. In particular, for a general crossover-process model that assumes only that there exists in each interval at most one crossover, we describe how to use the expectation-maximization algorithm to examine the probability distribution of the recombination events underlying meioses leading to UPD. We can also use this flexible approach to create genetic maps based on UPD data and to inspect recombination differences between meioses exhibiting UPD and normal meioses. The proposed method has been implemented in a computer program, and we illustrate the proposed approach through its application to a set of UPD15 data.
登录
查看更多内容
从重组数据估计减数分裂交换模式：对人类的应用。
影响因子：
3.3
作者：
Lamb,NE;Feingold,E;Sherman,SL
通讯作者：
Sherman,SL
影响因子：
9.8
作者：
Broman, KW;Weber, JL
通讯作者：
Weber, JL
有序四分体的统计分析。
影响因子：
3.3
作者：
Zhao,H;Speed,TP
通讯作者：
Speed,TP
影响因子：
4.4
作者：
CHAKRAVARTI A;SLAUGENHAUPT S A
通讯作者：
SLAUGENHAUPT S A
15 号染色体不分离：起源和重组。
影响因子：
9.8
作者：
Robinson,WP;Bernasconi,F;Mutirangura,A;Ledbetter,DH;Langlois,S;Malcolm,S;Morris,MA;Schinzel,AA
通讯作者：
Schinzel,AA