Phosphine-catalyzed domino reaction: an efficient method for the synthesis of highly functionalized spirooxazolines.
Phosphine-catalyzed domino reaction: an efficient method for the synthesis of highly functionalized spirooxazolines.
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DOI：
10.1039/c2ob26338f
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发表时间：
2012-08
影响因子：
3.2
通讯作者：
Lihua Yang;Peizhong Xie;Erqing Li;Xin Li;Y. Huang;Ruyu Chen
中科院分区：
文献类型：
--
作者：
Lihua Yang;Peizhong Xie;Erqing Li;Xin Li;Y. Huang;Ruyu Chen
发展了一种新的膦催化的炔酮与N-取代靛红的分子间[3 + 2]环加成反应。在该反应中，取代壬酮作为C（3）合成子，成功地应用于分子间成环反应。以高产率和立体选择性合成了一系列功能化的螺恶唑啉。
A novel phosphine-catalyzed intermolecular [3 + 2] cycloaddition of ynones and N-substituted isatins was developed. In this reaction, substituted ynones, serving as a C(3) synthon, were successfully applied in intermolecular annulation reactions. A number of functionalized spirooxazolines were obtained in high yields and stereoselectivity.