Chiral separation of α-cyclohexyl-mandelic-acid by aqueous two phase system combined with Cu2-β-cyclodextrin complex
Chiral separation of α-cyclohexyl-mandelic-acid by aqueous two phase system combined with Cu2-β-cyclodextrin complex
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DOI：
10.1016/j.cej.2012.09.058
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发表时间：
2012-11
影响因子：
15.1
通讯作者：
Liang-Hong Li;Fen-fang Li
中科院分区：
文献类型：
--
作者：
Liang-Hong Li;Fen-fang Li
基于聚乙二醇（PEG）-盐双水相体系（ATPS），提出了一种新的、绿色、经济的α-环己基扁桃酸（CHMA）手性分离和测定方法。结果表明，该新技术对CHMA具有良好的手性识别能力。PEG分子量、pH值、温度、Cu 2-β-环糊精用量等因素影响分离因子α，从而影响主客体复合物的形成和复合物的分布。本工作中，Cu ~（2-）-β-环糊精对R-CHMA有较好的识别作用。在最佳工艺条件下，一步萃取后，α可达1.36。该方法为外消旋化合物的制备分离探索了一条新的途径。
Based on the Polyethylene glycol (PEG)-salt aqueous two phase system (ATPS), a novel, green and economical approach was proposed for the chiral separation and determination of α-cyclohexyl-mandelic-acid (CHMA). The result showed that this new technique has good chiral recognition ability for CHMA. The separation factor, α, was affected by various factors, including the molecular weight of PEG, pH, temperature, the amount of Cu2-β-cyclodextrin, which influenced on either the formation of the host–guest complex or the distribution of the complex. In this work, Cu2-β-cyclodextrin was inclined to recognize R-CHMA. Under the optimum conditions, α could reached 1.36 after just one step extraction. This method has explored a new path for preparative separation of racemic compounds.