Anterior cingulate activity during error and autonomic response
Anterior cingulate activity during error and autonomic response
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DOI：
10.1016/j.neuroimage.2005.05.047
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发表时间：
2005-10-01
期刊：
影响因子：
5.7
通讯作者：
Dolan, RJ
中科院分区：
文献类型：
--
作者：
Critchley, HD;Tang, J;Dolan, RJ
前扣带皮层（ACC）对人类认知功能的贡献尚不清楚。头侧（rACC）和背侧（dACC）ACC皮质分别涉及由于情绪和认知干扰而需要增加反应控制的任务。然而，rACC和dACC都被诱导内脏唤醒变化的条件激活，这表明ACC支持产生整合的身体反应。为了澄清ACC功能的纯认知和心理生理学帐户之间的关系，我们使用功能性磁共振成像扫描15名受试者，而他们执行的Stroop任务的数字版本。为了指示自主觉醒，我们同时测量瞳孔直径。表现错误占了大部分的方差在一个瞳孔衍生的措施诱发自主觉醒。在功能成像数据的分析中，跨rACC和dACC的区域内的活动预测了自主反应幅度的试验变化，并且在错误试验期间得到增强，使用联合分析显示。rACC内其他位点的活动预测诱发自主觉醒，并显示出对错误的敏感性，但不符合标准。这些数据突出了ACC在错误处理的心理生理方面的作用，并表明，在ACC内存在一个接口之间的认知和生物行为系统的反应适应服务。(C)2005年爱思唯尔公司All rights reserved.
The contribution of anterior cingulate cortex (ACC) to human cognition remains unclear. The rostral (rACC) and dorsal (dACC) ACC cortex are implicated in tasks that require increased response control due to emotional and cognitive interference, respectively. However, both rACC and dACC are activated by conditions that induce changes in visceral arousal, suggesting that ACC supports a generation of integrated bodily responses. To clarify the relationship between purely cognitive and psychophysiological accounts of ACC function, we scanned 15 subjects using functional magnetic resonance imaging while they performed numerical versions of the Stroop task. To index autonomic arousal, we simultaneously measured pupil diameter. Performance errors accounted for most of the variance in a pupil-derived measure of evoked autonomic arousal. In analysis of the functional imaging data, activity within a region spanning rACC and dACC predicted trial-by-trial variation in autonomic response magnitude and was enhanced during error trials, shown using conjunction analyses. Activity within other loci within rACC predicted evoked autonomic arousal and showed sensitivity to errors but did not meet criteria for both. These data highlight the role of ACC in psychophysiological aspects of error processing and suggest that an interface exists within ACC between cognitive and biobehavioral systems in the service of response adaptation. (C) 2005 Elsevier Inc. All rights reserved.