Oesophageal motility defects associated with nocturnal gastro‐oesophageal reflux on proton pump inhibitors
Oesophageal motility defects associated with nocturnal gastro‐oesophageal reflux on proton pump inhibitors
复制标题
质子泵抑制剂与夜间胃食管反流相关的食管动力缺陷
DOI：
10.1046/j.1365-2036.1999.00641.x
复制
发表时间：
1999
影响因子：
7.6
通讯作者：
Donald O. Castell
中科院分区：
文献类型：
--
作者：
Y. M. Fouad;Philip O. Katz;Donald O. Castell
：我们实验室的最新研究表明，质子泵抑制剂上有70％的胃食管反思疾病（GERD）每天两次（B.D.）具有夜间胃酸突破（胃酸pH <4> 1 H）酸暴露于胃酸突破期间的GER的发病机理尚不清楚。
: Recent studies from our laboratory reveal that 70% of patients with gastro‐oesophageal reflux disease (GERD) on proton pump inhibitors twice daily (b.d.) have nocturnal gastric acid breakthrough (gastric pH < 4 > 1 h) which is often accompanied by oesophageal acid exposure. The pathogenesis of GER during gastric acid breakthrough is not clear.