Vitamin E, γ-tocopherol, diminishes ex vivo basophil response to dust mite allergen.
Vitamin E, γ-tocopherol, diminishes ex vivo basophil response to dust mite allergen.
复制标题
维生素 E、γ-生育酚可减少离体嗜碱性粒细胞对尘螨过敏原的反应。
作者：
Mills,K;Lay,J;Wu,W;Robinette,C;Kesic,MJ;Dreskin,SC;Peden,DB;Hernandez,M
Epidemiologic studies suggest that dietary vitamin E is a candidate intervention for atopic disease. We usedin vitroandex vivoexposures to test the hypothesis that the most common dietary isoform of vitamin E, γ‐tocopherol (γT), could suppress FcεRI‐mediated basophil activation. Rat basophilic leukemia (RBL)‐SX38 cells that express human FcεRI were treated with or without γT, followed by stimulation with α‐IgE. In theex vivostudy, 20Der f 1‐allergic volunteers consumed a γT‐enriched supplement for 7 days. Their basophils were challengedex vivowith α‐IgE and graded doses ofDer f1 before and after the supplementation period. γt treatment of RBL‐SX38 cells significantly reduced basophil degranulation and de novo TH2 cytokine production. Daily consumption of a γT‐rich supplement by dust mite‐allergic volunteers reduced basophil activation afterex vivodust mite challenge. Vitamin E supplements rich in γT may be useful adjuncts in decreasing atopic disease.
