MOUSE RETINOIC ACID RECEPTOR-ALPHA-2 ISOFORM IS TRANSCRIBED FROM A PROMOTER THAT CONTAINS A RETINOIC ACID RESPONSE ELEMENT
MOUSE RETINOIC ACID RECEPTOR-ALPHA-2 ISOFORM IS TRANSCRIBED FROM A PROMOTER THAT CONTAINS A RETINOIC ACID RESPONSE ELEMENT
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DOI：
10.1073/pnas.88.22.10138
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发表时间：
1991-11-01
影响因子：
11.1
通讯作者：
CHAMBON, P
中科院分区：
文献类型：
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作者：
LEROY, P;NAKSHATRI, H;CHAMBON, P
我们已经鉴定了小鼠维甲酸受体α-2(MRAR-α-2)亚型的启动子。这个启动子包含一个维甲酸反应元件(REARE)，它与RAR-β-2启动子中的REARE非常相似。此外，RAR-α-2和RAR-β-2近端启动子序列彼此相似，并产生各自起始点位于相似位置的转录本。RAR-α-2 Rare由两个直接重复的5‘-GTTCA-3’基序组成，在体外，所有三种RARs(α、β和伽马)都与其结合。
We have characterized the promoter of the mouse retinoic acid receptor alpha-2 (mRAR-alpha-2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-beta-2 promoter. Moreover, RAR-alpha-2 and RAR-beta-2 proximal promoter sequences are similar to each other and generate transcripts whose respective start sites are located at similar positions. The RAR-alpha-2 RARE consists of two directly repeated 5'-GTTCA-3' motifs to which all three RARs (alpha, beta, and gamma) bind in vitro.