Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients
Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients
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DOI：
10.2337/dc06-2247
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发表时间：
2007-05-01
期刊：
影响因子：
16.2
通讯作者：
Arcaro, Guido
中科院分区：
文献类型：
--
作者：
Targher, Giovanni;Bertolini, Lorenzo;Arcaro, Guido
目的-确定非酒精性脂肪肝（NAFLD）在2型糖尿病人群的患病率，并比较心血管疾病（CVD）的患病率和危险因素之间的人与非NAFLD.RESEARCH设计和方法-整个样本的2型糖尿病门诊患者（n = 2，839）定期参加我们的诊所进行了筛选。主要结局指标是NAFLD（根据患者病史和肝脏超声）和明显的CVD（根据患者病史、患者记录审查、心电图以及颈动脉和下肢动脉的回声多普勒扫描）。结果-参与者中NAFLD的未调整患病率为69.5%，NAFLD是超声检查中肝脏脂肪变性最常见的原因（81.5%）。NAFLD的患病率随着年龄的增长而增加（40-59岁的参与者为65.4%，≥ 60岁的参与者为74.6%; P < 0.001），年龄校正的NAFLD患病率男性为71.1%，女性为68%。与非NAFLD患者相比，NAFLD患者的年龄和性别调整后的冠状动脉（26.6 vs. 18.3%）、脑血管（20.0 vs. 13.3%）和外周血管（15.4 vs. 10.0%）疾病患病率显著（P < 0.001）更高。在逻辑回归分析中，NAFLD与流行的心血管疾病独立的经典危险因素，血糖控制，药物治疗，代谢综合征features.CONCLUSIONS - NAFLD是非常常见的2型糖尿病患者，并与较高的心血管疾病的患病率。后续研究需要确定NAFLD是否预测CVD的发展和进展。
OBJECTIVE - To determine the prevalence of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetic population and to compare the prevalence of cardiovascular disease (CVD) and its risk factors between people with and without NAFLD.RESEARCH DESIGN AND METHODS - The entire sample of type 2 diabetic outpatients (n = 2,839) who regularly attended our clinic was screened. Main outcome measures were NAFLD (by patient history and liver ultrasound) and manifest CVD (by patient history, review of patient records, electrocardiogram, and echo-Doppler scanning of carotid and lower limb arteries).RESULTS - The unadjusted prevalence of NAFLD was 69.5% among participants, and NAFLD was the most common cause (81.5%) of hepatic steatosis on ultrasound examination. The prevalence of NAFLD increased with age (65.4% among participants aged 40-59 years and 74.6% among those aged >= 60 years; P < 0.001) and the age-adjusted prevalence of NAFLD was 71.1% in men and 68% in women. NAFLD patients had remarkably (P < 0.001) higher age and sex-adjusted prevalences of coronary (26.6 vs. 18.3%), cerebrovascular (20.0 vs. 13.3%), and peripheral (15.4 vs. 10.0%) vascular disease than their counterparts without NAFLD. In logistic regression analysis, NAFLD was associated with prevalent CVD independent of classical risk factors, glycemic control, medications, and metabolic syndrome features.CONCLUSIONS - NAFLD is extremely common in people with type 2 diabetes and is associated with a higher prevalence of CVD. Follow-up studies are needed to determine whether NAFLD predicts the development and progression of CVD.