Does architectural lighting contribute to breast cancer?
Does architectural lighting contribute to breast cancer?
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DOI：
10.1186/1477-3163-5-20
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发表时间：
2006-08-10
影响因子：
--
通讯作者：
Bullough, John D
中科院分区：
文献类型：
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作者：
Figueiro, Mariana G;Rea, Mark S;Bullough, John D
人们越来越关注光线对夜间褪黑激素产生的影响，或许也因此影响了现代社会中乳腺癌的发病率。然而，这个逻辑链中的直接因果关系尚未完全建立，最薄弱的环节是无法定量地指定建筑照明作为昼夜节律系统的刺激。本文的目的是提请注意这一弱点。我们回顾了有关褪黑素、夜间光线与人类癌症风险和动物肿瘤生长之间关系的文献。更具体地说，我们关注的是光线对人类夜间褪黑激素抑制的影响，以及这些数据在现实生活中对女性的适用性。还报告了妇女在工作和家庭的照明环境中的光度测量数据。文献综述和测量数据表明，需要更多的定量知识来了解现代社会中妇女和女孩实际经历的昼夜节律光暴露。如果没有这样的定量知识，从流行病学研究和使用动物模型的参数研究中可以获得关于褪黑激素与乳腺癌病因之间因果关系的有限见解。
There is a growing interest in the role that light plays on nocturnal melatonin production and, perhaps thereby, the incidence of breast cancer in modern societies. The direct causal relationships in this logical chain have not, however, been fully established and the weakest link is an inability to quantitatively specify architectural lighting as a stimulus for the circadian system. The purpose of the present paper is to draw attention to this weakness. We reviewed the literature on the relationship between melatonin, light at night, and cancer risk in humans and tumor growth in animals. More specifically, we focused on the impact of light on nocturnal melatonin suppression in humans and on the applicability of these data to women in real-life situations. Photometric measurement data from the lighted environment of women at work and at home is also reported. The literature review and measurement data demonstrate that more quantitative knowledge is needed about circadian light exposures actually experienced by women and girls in modern societies. Without such quantitative knowledge, limited insights can be gained about the causal relationship between melatonin and the etiology of breast cancer from epidemiological studies and from parametric studies using animal models.