Insights into the Role of Commensal-Specific T Cells in Intestinal Inflammation.
Insights into the Role of Commensal-Specific T Cells in Intestinal Inflammation.
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DOI：
10.2147/jir.s288288
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发表时间：
2022
影响因子：
4.5
通讯作者：
Konnikova L
中科院分区：
文献类型：
--
作者：
Gehlhaar A;Inala A;Llivichuzhca-Loja D;Silva TN;Adegboye CY;O'Connell AE;Konnikova L
Trillions of microorganisms exist in the human intestine as commensals and contribute to homeostasis through their interactions with the immune system. In this review, we use previous evidence from published papers to elucidate the involvement of commensal-specific T cells (CSTCs) in regulating intestinal inflammatory responses. CSTCs are generated centrally in the thymus or peripherally at mucosal interfaces and present as CD4+ or CD8+ T cells. Bacteria, fungi, and even viruses act commensally with humans, warranting consideration of CSTCs in this critical relationship. Dysregulation of this immunological balance can result in both intestinal inflammation or damaging autoimmune responses elsewhere in the body. Given the relative novelty of CSTCs in the literature, we aim to introduce the importance of their role in maintaining immune homeostasis at barrier sites such as the intestine.
