MANAGEMENT OF NONFUNCTIONING NEUROENDOCRINE TUMORS OF THE PANCREAS
MANAGEMENT OF NONFUNCTIONING NEUROENDOCRINE TUMORS OF THE PANCREAS
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DOI：
10.1002/bjs.1800800528
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发表时间：
1993-05-01
影响因子：
9.6
通讯作者：
WILLIAMSON, RCN
中科院分区：
文献类型：
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作者：
CHESLYNCURTIS, S;SITARAM, V;WILLIAMSON, RCN
1982年至1991年，20例中位年龄为44岁（范围22-76）的胰腺无功能神经内分泌肿瘤患者接受了治疗。表现为梗阻性黄疸（7例）、腹痛（7例）、体重减轻（6例）、腹部肿块（8例）和严重出血（4例）。肠道激素谱是正常的，除了一个病人谁有胰腺多肽水平升高。对比增强计算机断层扫描定位肿瘤17例，内脏血管造影14 15;所有，但三个肿瘤高度血管。10例患者接受了根治性切除术，其余患者通过切除术（4例）、旁路手术（3例）或单纯活检（3例）进行姑息性治疗。术后死亡2例，早期并发症7例。其余18例患者中有7例在发病后中位数16个月（范围4-30）死于疾病。11名幸存者，其中8人进行了根治性切除术，已随访中位数为42个月（范围7-72）。10名患者没有症状，但只有5名患者没有患病。这些肿瘤很少能通过根治性手术治愈，但患者可能多年没有症状。
Between 1982 and 1991, 20 patients of median age 44 (range 22-76) years were treated for non-functioning neuroendocrine tumours of the pancreas. Presenting features were obstructive jaundice (seven patients), abdominal pain (seven), weight loss (six), abdominal mass (eight) and severe haemorrhage (four). Gut hormone profiles were normal except for one patient who had a raised pancreatic polypeptide level. Contrast-enhanced computed tomography localized the tumour in 17 patients and visceral angiography in 14 of 15; all but three tumours were highly vascular. Ten patients underwent curative resection, and the remainder were managed palliatively by resection (four), bypass procedures (three) or biopsy alone (three). There were two postoperative deaths and seven early complications. Seven of the remaining 18 patients have died from disease a median of 16 (range 4-30) months after presentation. The 11 survivors, eight of whom had curative resections, have been followed for a median of 42 (range 7-72) months. Ten patients are asymptomatic but only five are free from disease. These tumours are seldom curable by radical surgery, but patients may remain free from symptoms for many years.