Changes in apomorphine pharmacodynamics following repeated treatment in 6-hydroxydopamine-lesioned rats
Changes in apomorphine pharmacodynamics following repeated treatment in 6-hydroxydopamine-lesioned rats
复制标题
6-羟基多巴胺损伤大鼠重复治疗后阿扑吗啡药效学的变化
DOI：
10.1016/0006-8993(96)00421-0
复制
发表时间：
1996
期刊：
影响因子：
2.9
通讯作者：
S. Youngman
中科院分区：
文献类型：
--
作者：
S. Gancher;A. Mayer;S. Youngman
对6-OHDA病变大鼠进行阿波啡反复治疗，比较治疗前后的量效关系，以更好地了解致敏的药理学机制。反复治疗后，观察到旋转行为的幅度和持续时间逐渐增加，并与阿扑吗啡剂量-反应曲线的非平行（向上）移动有关。这些变化与药物效力的简单变化不一致，而更符合阿波啡刺激突触后纹状体传出通路的能力变化，这是由反复给药引起的。
Rats with 6-OHDA lesions were repeatedly treated with apomorphine and dose-response relationships compared before and after treatment to better understand the pharmacological mechanisms which result in sensitization. A progressive increase in the magnitude and duration of rotational behavior was observed following repeated treatment and was associated with a nonparallel (upward) shift in apomorphine dose-response curves. These changes are inconsistent with simple shifts in drug potency, and instead are more consistent with changes in the ability of apomorphine to stimulate postsynaptic, striatal efferent pathways which result from repeated drug administration.
对单次和重复安非他明给药反应的个体差异：行为特征和神经化学相关性。
DOI：
--
发表时间：
1987
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Segal,DS;Kuczenski,R
通讯作者：
Kuczenski,R
连续暴露于选择性 D1 和 D2 多巴胺能激动剂对超敏感小鼠旋转行为的影响。
DOI：
--
发表时间：
1989
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Winkler,JD;Weiss,B
通讯作者：
Weiss,B