SERINE DERIVED OXAZOLIDINES AS SECONDARY STRUCTURE DISRUPTING, SOLUBILIZING BUILDING-BLOCKS IN PEPTIDE-SYNTHESIS
SERINE DERIVED OXAZOLIDINES AS SECONDARY STRUCTURE DISRUPTING, SOLUBILIZING BUILDING-BLOCKS IN PEPTIDE-SYNTHESIS
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DOI：
10.1016/s0040-4039(00)91681-2
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发表时间：
1992-03-17
影响因子：
1.8
通讯作者：
MUTTER, M
中科院分区：
文献类型：
--
作者：
HAACK, T;MUTTER, M
将丝氨酸作为恶唑烷保护的“假脯氨酸”掺入宿主肽中会导致二级结构形成的破坏，从而增加肽链的溶剂化。 这种对丝氨酸、苏氨酸或半胱氨酸的保护技术的使用代表了调节肽的构象和物理化学性质的强大工具。
The incorporation of serine as oxazolidine protected ''pseudo proline'' in a host peptide results in the disruption of secondary structure formation thus increasing the solvation of the peptide chain. The use of this protection technique for serine, threonine or cysteine represents a powerful tool to modulate the conformational and physico- chemical properties of peptides.