Passive immunization of newborn rhesus macaques prevents oral simian immunodeficiency virus infection.
Passive immunization of newborn rhesus macaques prevents oral simian immunodeficiency virus infection.
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新生恒河猴的被动免疫可预防口腔猿猴免疫缺陷病毒感染。
DOI：
10.1086/515270
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Marthas,ML
中科院分区：
文献类型：
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作者：
VanRompay,KK;Berardi,CJ;Dillard-Telm,S;Tarara,RP;Canfield,DR;Valverde,CR;Montefiori,DC;Cole,KS;Montelaro,RC;Miller,CJ;Marthas,ML
为了确定被动获得的抗病毒抗体是否调节人类儿科AIDS的病毒传播和疾病进展，测试了在新生恒河猴中用超免疫血清进行的前和后被动免疫预防口服猿猴免疫缺陷病毒（SIV）感染或疾病进展的潜力。未经治疗的新生儿在口服SIV接种后感染，并有高病毒血症，大多数动物在3个月内发展为致命的艾滋病。与此相反，SIV超免疫血清皮下接种前口服SIV保护6新生儿免受感染。当口服SIV接种后3周将这种SIV超免疫血清给予3名新生儿时，病毒血症没有减少，所有3名婴儿都在3个月内死于AIDS和免疫复合物疾病。这些结果表明，被动获得性抗人类免疫缺陷病毒（HIV）IgG可能会减少围产期HIV传播。然而，抗HIV IgG可能不会给已确诊HIV感染的婴儿带来治疗益处。
To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression in newborn rhesus macaques was tested. Untreated neonates became infected after oral SIV inoculation and had high viremia, and most animals developed fatal AIDS within 3 months. In contrast, SIV hyperimmune serum given subcutaneously prior to oral SIV inoculation protected 6 newborns against infection. When this SIV hyperimmune serum was given to 3 newborns 3 weeks after oral SIV inoculation, viremia was not reduced, and all 3 infants died within 3 months of age due to AIDS and immune-complex disease. These results suggest that passively acquired antihuman immunodeficiency virus (HIV) IgG may decrease perinatal HIV transmission. However, anti-HIV IgG may not impart therapeutic benefit to infants with established HIV infection.