Agrin in the CNS: a protein in search of a function?

Agrin in the CNS: a protein in search of a function?
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中枢神经系统中的集聚蛋白:寻找功能的蛋白质?

DOI:
10.1097/00001756-200208270-00001
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发表时间:
2002
期刊:
影响因子:
1.7
通讯作者:
Hilgenberg,LutzGW
Hilgenberg,LutzGW
中科院分区:
医学4区
文献类型:
--
作者:
Smith,MartinA;Hilgenberg,LutzGW

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The extracellular matrix molecule agrin mediates the motor neuron induced accumulation of acetylcholine receptors (AChR) at the neuromuscular junction. Agrin is also present in the CNS. However, while its spatiotemporal pattern of expression is consistent with a function in neuron–neuron synapse formation, it also suggests a role for agrin in other aspects of neural tissue morphogenesis. Here we review the data supporting these synaptic and non-synaptic functions of agrin in the CNS. The results of studies aimed at identifying a neuronal receptor for agrin (NRA) and its associated signal transduction pathways are examined. Possible roles for agrin in the etiology of diseases affecting the brain are also discussed.
在青蛙神经肌肉接头处的雪旺细胞突起的抗聚集蛋白染色下未观察到乙酰胆碱受体的聚集。
DOI: --
发表时间: 1999
期刊: Journal of neurobiology.
影响因子: --
作者:
Werle,MJ;Jones,MA;Stanco,AM
通讯作者: Stanco,AM
agrin 的层粘连蛋白结合域在结构上与 N-TIMP-1 相关
DOI: 10.1038/90422
发表时间: 2001
期刊: Nature Structural Biology
影响因子: --
作者:
J. Stetefeld;M. Jenny;T. Schulthess;R. Landwehr;B. Schumacher;S. Frank;M. Rüegg;J. Engel;R. Kammerer
通讯作者: R. Kammerer
DOI: 10.1083/jcb.78.1.176
发表时间: 1978-07
期刊: The Journal of cell biology
影响因子: --
作者:
Sanes JR;Marshall LM;McMahan UJ
通讯作者: McMahan UJ
DOI: --
发表时间: 1993
期刊: The Journal of biological chemistry
影响因子: --
作者:
Ma,J;Nastuk,MA;McKechnie,BA;Fallon,JR
通讯作者: Fallon,JR
选择性剪接在调节集聚蛋白与肌肉细胞结合中的作用。
DOI: 10.1016/s0165-3806(98)00105-9
发表时间: 1998
期刊: Brain research. Developmental brain research
影响因子: --
作者:
Deyst,KA;McKechnie,BA;Fallon,JR
通讯作者: Fallon,JR