Dietary catechins in relation to coronary heart disease death among postmenopausal women
Dietary catechins in relation to coronary heart disease death among postmenopausal women
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DOI：
10.1097/00001648-200111000-00015
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发表时间：
2001-11-01
期刊：
影响因子：
5.4
通讯作者：
Folsom, AR
中科院分区：
文献类型：
--
作者：
Arts, ICW;Jacobs, DR;Folsom, AR
儿茶素是类黄酮的主要类别之一，是存在于各种植物性食品和饮料中的生物活性化合物。实验数据表明，它们可能预防人类的慢性疾病。在一项对爱荷华州绝经后妇女的前瞻性研究中，我们研究了儿茶素的摄入量是否与冠心病死亡风险呈负相关。在1986年至1998年期间，34,492名最初没有心血管疾病的参与者中，有767人死于冠心病。（+）-儿茶素和(-)-表儿茶素的摄入与冠心病死亡之间存在很强的负相关关系，多因素调整后这种关系有所减弱（从最低到最高五分位数的风险比：1.00、0.95、0.97、0.77、0.76）。这种负相关在冠心病风险较低的女性（不吸烟，没有糖尿病和心血管疾病）中最为明显。大量摄入“没食子酸酯”（茶中典型的儿茶素）与冠心病死亡无关。在儿茶素的主要来源中，苹果和葡萄酒与冠心病死亡呈负相关。我们的数据表明，预防效果可能仅限于某些类型的儿茶素，或者这些是其他饮食成分或一般健康生活方式的指标。
Catechins, one of the major groups of flavonoids, are bioactive compounds present in a variety of plant foods and beverages. Experimental data suggest that they might prevent chronic diseases in humans. We studied whether the intake of catechins was inversely associated with the risk of coronary heart disease death in a prospective study of postmenopausal women from Iowa. Between 1986 and 1998, 767 of 34,492 participants initially free of cardiovascular diseases died from coronary heart disease. There was a strong inverse association between the intake of (+)-catechin and (-)-epicatechin and coronary heart disease death, which was somewhat attenuated after multivariate adjustment (risk ratios from lowest to highest quintile: 1.00, 0.95, 0.97, 0.77, 0.76). This inverse association was most pronounced in women at low risk of coronary heart disease (non-smokers, free of diabetes mellitus and cardiovascular diseases), A high intake of "gallates," catechins typical of tea, was not associated with coronary heart disease death. Of the major catechin sources, apples and wine were inversely associated with coronary heart disease death. Our data suggest that preventive effects might be limited to certain types of catechins, or that these are indicators of other dietary components or a healthy lifestyle in general.