SUSCEPTIBILITY OF 5 STRAINS OF MICE TO BABESIA-MICROTI OF HUMAN-ORIGIN
SUSCEPTIBILITY OF 5 STRAINS OF MICE TO BABESIA-MICROTI OF HUMAN-ORIGIN
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DOI：
10.2307/3280290
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发表时间：
1979-01-01
影响因子：
1.3
通讯作者：
HANSON, WL
中科院分区：
文献类型：
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作者：
RUEBUSH, MJ;HANSON, WL
对1个近交系(CF1)和4个近交系(BALB/c、C57、CBA和C3H)小鼠进行了人源性微小芽孢杆菌的敏感性试验。其中，完整的C3H小鼠的寄生虫血症高于所有其他完整的小鼠，而BALB/c小鼠在切除脾的小鼠中患上最高的寄生虫血症。易感性与H-2单倍型无明显相关性。由于C3H和BALB/c小鼠出现了相对较高的初始峰值寄生虫，为了提高寄生虫的毒力，在这两个品系中进行了连续传代。在BALB/c中传代30次，在C3H小鼠中传代49次，12个月内最大寄生虫数比最初观察到的高出50倍。在这两种小鼠适应寄生虫的最高寄生率稳定后，确定最大寄生虫血症的开始和水平与接种寄生虫数的关系。对于C3H和BALB/c适应的寄生虫，随着接种量的增加，达到最大寄生血症所需的时间减少，最大寄生血症水平增加。用适应于异种小鼠品系的寄生虫感染任一品系小鼠的研究表明，C3H小鼠比BALB/c小鼠对同源或异种寄生虫更敏感。微小芽孢杆菌对小鼠的毒力可通过在该宿主中长时间传代而增加。一旦适应了这种宿主物种，毒力似乎更多地依赖于小鼠品系的先天易感性，而不是寄生虫对特定品系小鼠的适应。
One outbred (CF1) and 4 inbred (BALB/c, C57, CBA and C3H) strains of mice were tested for susceptibility to B. microti of human origin. Of these, intact C3H mice developed higher parasitemia than all other intact mice, while BALB/c mice developed the highest parasitemia among splenectomized mice. Susceptibility was not related to H-2 haplotype in any obvious way. Because C3H and BALB/c mice developed relatively high initial peak parasitemias, the parasite was serially passaged in both of these mouse strains in an attempt to increase parasite virulence. After 30 passages in BALB/c and 49 passages in C3H mice over a period of 12 mo., maximum parasitemias were 50 times higher than those observed initially. After the peak parasitemias of these 2 mouse-adapted parasites had stabilized, the relationship between onset and level of maximum parasitemia and number of parasites inoculated was determined. With both C3H- and BALB/c-adapted parasites, as inoculum size increased, the time required to reach maximum parasitemia decreased and the level of maximum parasitemia increased. Studies involving infection of either mouse strain with parasites adapted to the heterologous mouse strain indicated that C3H mice were more susceptible than BALB/c mice to homologous or heterologous parasites. The virulence of B. microti to the mouse may be increased by prolonged passage in this host. Once adaptation to this host species has occurred, virulence appears to be more dependent on the innate susceptibility of the mouse strain than on adaptation of parasites to a particular strain of mouse.