Association between echo intensity and attenuation of skeletal muscle in young and older adults: a comparison between ultrasonography and computed tomography.
Association between echo intensity and attenuation of skeletal muscle in young and older adults: a comparison between ultrasonography and computed tomography.
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DOI：
10.2147/cia.s173372
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发表时间：
2018
影响因子：
3.6
通讯作者：
Kimura M
中科院分区：
文献类型：
--
作者：
Watanabe Y;Ikenaga M;Yoshimura E;Yamada Y;Kimura M
随着年龄的增长，骨骼肌会经历量和质的变化。通过超声检查（US）获得的骨骼肌回波强度（EI）被认为可以反映肌肉质量。该技术是非侵入性的，易于使用，并且比计算机断层扫描 (CT) 等其他成像技术相对便宜。先前的研究表明，EI 与多种身体表现有关。然而，很少有研究调查 EI 相对于其他成像方法在骨骼肌成像方面的有效性。我们比较了 US 和 CT 成像系统评估的定量和定性指标，以加强其有效性。共有 40 名成年人参与了这项研究：19 名年轻人（10 名男性和 9 名女性；平均（±SD）年龄为 22.7±1.5 岁）和 21 名老年人（13 名男性和 8 名女性；平均年龄为 70.6±4.8 岁）。使用 US 和 CT 成像系统对每位参与者的两条大腿进行评估。就US指数而言，年轻组的大腿前部肌肉厚度（MT）显着高于老年组（P<0.001），而EI则显着低于老年组（P=0.001）。在CT指数方面，年轻组的肌肉横截面积（CSA）和平均CT值（Hounsfield单位[HU]）显着高于老年组（P<0.001），而低密度肌肉面积百分比（%LDMA）显着高于老年组（P<0.001）。 MT 与 CSA 之间存在显着且强的正相关关系，反映了肌肉数量（r=0.774；P<0.001）。对于肌肉质量指标，我们发现 EI 和 CT 值之间（r=-0.502；P<0.001）以及 EI 和 %LDMA 之间（r=0.441；P<0.001）之间存在显着和中度相关性。然而，这些相关性在老年组中被发现降低[EI 和 CT 值之间（r=-0.363；P=0.018）以及 EI 和 %LDMA 之间（r=0.257；P=0.100）]。这项研究的结果表明，根据 CT 评估，EI 与肌肉衰减呈中度相关，这意味着较高的 EI 至少部分反映了肌内脂质浸润。
Skeletal muscle experiences both quantitative and qualitative changes with aging. Echo intensity (EI) of the skeletal muscle obtained by ultrasonography (US) has been considered to reflect muscle quality. This technique is noninvasive, easily accessible, and is relatively inexpensive than that of other imaging techniques such as computed tomography (CT). Previous studies have reported that EI is related to several physical performances. However, few studies have investigated the validity of EI against other imaging methods in case of imaging of the skeletal muscle. We compared quantitative and qualitative indices evaluated by the US and CT imaging systems to strengthen their validity. A total of 40 adults participated in this study: 19 young (10 men and 9 women; their mean (±SD) age was 22.7±1.5 years) and 21 older adults (13 men and 8 women; their mean age was 70.6±4.8 years). Both thighs of each participant were evaluated using US and CT imaging systems. With respect to the US indices, the young group had significantly higher muscle thickness (MT) of the front thigh (P<0.001) and lower EI (P=0.001) than that of the older group. With respect to the CT indices, the cross-sectional area (CSA) and mean CT value (Hounsfield unit [HU]) of the muscle were found to be significantly higher in the young group (P<0.001) than that of the older group, whereas the percentage of low-density muscle area (%LDMA) was found to be significantly higher in the older group (P<0.001) than that of the young group. A significant, strong, and positive correlation was observed between MT and CSA, which reflects the muscle quantity (r=0.774; P<0.001). With respect to the indices of muscle quality, we found significant and moderate correlations between EI and CT values (r=−0.502; P<0.001) and between EI and %LDMA (r=0.441; P<0.001). However, these correlations were found to be decreased in the older group [between EI and CT value (r=−0.363; P=0.018) and between EI and %LDMA (r=0.257; P=0.100)]. Results of this study indicate that the EI is moderately associated with muscle attenuation as assessed by CT, which means that higher EI at least partly reflects intramuscular lipid infiltration.