Reduced Tolerance to Night Shift in Chronic Shift Workers: Insight From Fractal Regulation
Reduced Tolerance to Night Shift in Chronic Shift Workers: Insight From Fractal Regulation
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DOI：
10.1093/sleep/zsx092
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发表时间：
2017-07-01
期刊：
影响因子：
5.6
通讯作者：
Hu, Kun
中科院分区：
文献类型：
--
作者：
Li, Peng;Morris, Christopher J.;Hu, Kun
研究目的：健康生理学的特征在于分形调节（FR），其在不同时间尺度的生理输出的波动中产生相似的结构。扰动的FR与衰老和年龄相关的病理状况相关。轮班工作，涉及重复和长期暴露于失调的环境和行为周期，扰乱昼夜协调。我们测试是否夜班扰动FR在运动活动和夜班是否影响FR在慢性轮班工人和non-shift workers different.Methods：我们研究了13个慢性轮班工人和14个non-shift workers作为对照，使用现场和实验室实验。在实验室研究中，模拟夜班被用来诱导内源性昼夜节律起搏器和睡眠-觉醒周期之间的不一致（即，昼夜失调），而环境条件和食物摄入量controlled.Results：在现场研究中，我们发现，FR是强大的控制，但打破了在夜班工人，导致更多的随机活动波动观察痴呆症患者。夜班效应甚至在夜班结束后2天仍存在。在实验室研究证实，夜班扰乱FR在慢性轮班工人，并表明FR在控制更弹性的昼夜失调。此外，FR在真实的和模拟的夜班更不安，在那些谁开始轮班工作在老年人ages.Conclusions：慢性轮班工作导致夜班不耐受，这可能是与昼夜节律控制系统的可塑性下降。
Study Objectives: Healthy physiology is characterized by fractal regulation (FR) that generates similar structures in the fluctuations of physiological outputs at different time scales. Perturbed FR is associated with aging and age-related pathological conditions. Shift work, involving repeated and chronic exposure to misaligned environmental and behavioral cycles, disrupts circadian coordination. We tested whether night shifts perturb FR in motor activity and whether night shifts affect FR in chronic shift workers and non-shift workers differently.Methods: We studied 13 chronic shift workers and 14 non-shift workers as controls using both field and in-laboratory experiments. In the in-laboratory study, simulated night shifts were used to induce a misalignment between the endogenous circadian pacemaker and the sleep-wake cycles (ie, circadian misalignment) while environmental conditions and food intake were controlled.Results: In the field study, we found that FR was robust in controls but broke down in shift workers during night shifts, leading to more random activity fluctuations as observed in patients with dementia. The night shift effect was present even 2 days after ending night shifts. The in-laboratory study confirmed that night shifts perturbed FR in chronic shift workers and showed that FR in controls was more resilience to the circadian misalignment. Moreover, FR during real and simulated night shifts was more perturbed in those who started shift work at older ages.Conclusions: Chronic shift work causes night shift intolerance, which is probably linked to the degraded plasticity of the circadian control system.