Quality of life, anxiety, and depression in patients with an untreated intracranial aneurysm or arteriovenous malformation
Quality of life, anxiety, and depression in patients with an untreated intracranial aneurysm or arteriovenous malformation
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DOI：
10.1161/hs0202.102335
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发表时间：
2002-02-01
期刊：
影响因子：
8.3
通讯作者：
van Gijn, J
中科院分区：
文献类型：
--
作者：
van der Schaaf, IC;Brilstra, EH;van Gijn, J
背景和目的--本研究的目的是评估意识到动脉瘤或动静脉畸形存在的患者的健康相关生活质量以及焦虑和抑郁症状。方法：对参与者进行回顾性鉴定，并邀请他们参与研究；同意的参与者通过面对面的2份问卷进行访谈，评估健康相关的生活质量(疾病影响量表[SIP]和MOS简表[SF-36])和心理状态(医院焦虑和抑郁量表[HADS])。我们使用学生t检验统计来比较研究人群和参考人群的分数。结果：我们确定了21名患者，其中9名患者患有动脉瘤，12名患者患有动静脉畸形。与参考人群相比，这些患者的睡眠和休息生活质量降低(差异为6.8；95%可信区间，3.1~10.5)、情绪行为(10.1；95%可信区间，5.7~14.6)、流动性(5，4；95%可信区间，2.1~8.7)、社交(5.3；95%可信区间，1.6~8.9)和警觉行为(11.9；95%可信区间，6.2~17.5)。SIP心理社会分值(7.1；95%CI，3.9~10.2)和总分(4.7；95%CI，2.2~7.2)也显著受损。在SF-36领域，与参考人群相比，社会功能显著降低(8.9；95%CI，0.1至17.7)。抑郁的HADS评分在患者和参考人群中是相似的。结论-我们的研究表明，了解到存在未闭塞的未经治疗的颅内动脉瘤或动静脉畸形会降低生活质量，最显著的是在心理社会领域，而不会导致焦虑和抑郁水平的显著提高。
Background and Purpose-The objective of this study was to assess the health-related quality of life and symptoms of anxiety and depression in patients who are aware of the presence of a patent aneurysm or arteriovenous malformation.Methods-Participants were retrospectively identified and invited to participate in the study; consenting participants were interviewed in a face-to-face setting by means of 2 questionnaires assessing health-related quality of life (Sickness Impact Profile [SIP] and the MOS Short Form-36 [SF-36]) and psychological state (Hospital Anxiety and Depression Scale [HADS]). We used Student's t test statistics to compare the scores of the study population with the scores of reference populations.Results-We identified 21 patients, of whom 9 had an aneurysm and 12 had an arteriovenous malformation. Compared with the reference population, these patients had a reduced quality of life for sleep and rest (difference of SIP means, 6.8; 95% CI, 3.1 to 10.5), emotional behavior (10.1; 95% CI, 5.7 to 14.6), mobility (5,4; 95% CI, 2.1 to 8.7), social interactions (5.3; 95% CI, 1.6 to 8.9), and alertness behavior (11.9; 95% CI, 6.2 to 17.5). The SIP psychosocial subscore (7.1; 95% CI, 3.9 to 10.2) and total SIP score (4.7; 95% CI, 2.2 to 7.2) were also significantly impaired. For the SF-36 domains, social functioning was significantly decreased compared with the reference population (8.9; 95% CI, 0.1 to 17.7). HADS scores for depression were similar for patients and the reference population.Conclusions-Our study shows that knowledge of harboring an unoccluded untreated intracranial aneurysm or arteriovenous malformation reduces quality of life, most prominently on the psychosocial domains, without leading to substantially raised levels of anxiety and depression.