Synthesis of Aminoquercetin for Reducing Side Effects of Cancer Radiation Therapy
Synthesis of Aminoquercetin for Reducing Side Effects of Cancer Radiation Therapy
复制标题
合成氨基槲皮素以减少癌症放射治疗的副作用
DOI：
10.1016/j.freeradbiomed.2016.10.252
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发表时间：
2016
影响因子：
7.4
通讯作者：
今井 耕平，中西 郁夫，山本 奈知，松本 謙一郎，福原 潔
中科院分区：
文献类型：
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作者：
Kohei Imai;Ikuo Nakanishi;Kei Ohkubo;Yusuke Ohba;Takuya Arai;Mirei Mizuno;Shunichi Fukuzumi;Ken-ichiro;and Matsumoto;Kiyoshi Fukuhara;水野 美麗，中西 郁夫，松林 智子，今井 耕平，荒井 卓也，松本 謙一郎，福原 潔;今井 耕平，中西 郁夫，山本 奈知，松本 謙一郎，福原 潔
放射治疗是一种使用高能辐射杀死癌细胞的癌症治疗方法。羟基自由基和其他可扩散自由基的产生是癌症辐射损伤的主要原因。然而，正常细胞也会受到放射治疗的影响，这就是在此类治疗中观察到的不良副作用的原因。抗氧化剂具有减少放射治疗产生的自由基的能力，从而降低癌细胞治疗的有效性。如果癌细胞中抗氧化剂的自由基清除活性受到抑制，则可以将它们与放射癌症治疗结合使用，以减少不良副作用。在这项研究中，我们设计了一种槲皮素衍生物，其自由基清除活性在癌症细胞等酸性条件下会降低。将介绍槲皮素衍生物的合成和自由基清除活性。
Radiation therapy is a cancer treatment in which a high-energy radiation is used to kill cancer cells. The production of hydroxyl radicals and other diffusible radicals is a principal cause of radiation damage to cancer. However, normal cells are affected by radiation therapy as well, and this accounts for the adverse side effects observed in this type of treatment.Antioxidants exhibit an ability to reduce free radicals generated by radiotherapy, and thereby decrease the effectiveness of the therapy in cancer cells. If the radical scavenging activity of antioxidants is inhibited in cancer cells, they can be used in combination with radiation cancer therapy to reduce the adverse side effects. In this study, we designed a quercetin derivative, whose radical scavenging activity was decreased under acidic conditions such as caner cells. The synthesis and radical scavenging activity of the quercetin derivative will be presented.