IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy
IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy
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DOI：
10.1016/s1074-7613(01)00109-1
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发表时间：
2001-03-01
期刊：
影响因子：
32.4
通讯作者：
Dalla-Favera, R
中科院分区：
文献类型：
--
作者：
Hatzivassiliou, G;Miller, I;Dalla-Favera, R
染色体1 q21缺失在B细胞恶性肿瘤中很常见，但其靶基因尚不清楚。通过克隆骨髓瘤细胞系中a（1;14）（q21;q32）染色体易位的断点，我们已经鉴定了两个新基因，IRTA 1和IRTA 2，编码与Fc和抑制性受体家族同源的细胞表面受体。两种基因在成熟B细胞中选择性表达：IRTA 1在边缘区B细胞中表达，IRTA 2在中心细胞、边缘区B细胞和免疫母细胞中表达。作为t（1;14）的结果，IRTA 1融合到免疫球蛋白C α结构域以产生嵌合IRTA 1/C α融合蛋白。在1 q21异常的肿瘤细胞系中，IRTA 2表达失调。因此，IRTA 1和IRTA 2是与B细胞发育和淋巴瘤发生有关的新型免疫受体。
Abnormalities of chromosome 1q21 are common in B cell malignancies, but their target genes are largely unknown. By cloning the breakpoints of a (1;14) (q21;q32) chromosomal translocation in a myeloma cell line, we have identified two novel genes, IRTA1 and IRTA2, encoding cell surface receptors homologous to the Fc and inhibitory receptor families. Both genes are selectively expressed in mature B cells: IRTA1 in marginal zone B cells and IRTA2 in centrocytes, marginal zone B cells, and immunoblasts. As a result of the t(1;14), IRTA1 is fused to the immunoglobulin C alpha domain to produce a chimeric IRTA1/C alpha fusion protein. In tumor cell lines with 1q21 abnormalities, IRTA2 expression is deregulated. Thus, IRTA1 and IRTA2 are novel immunoreceptors implicated in B cell development and lymphomagenesis.