Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women - A randomized trial
Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women - A randomized trial
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DOI：
10.1001/jama.289.14.1799
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发表时间：
2003-04-09
影响因子：
120.7
通讯作者：
Giugliano, D
中科院分区：
文献类型：
--
作者：
Esposito, K;Pontillo, A;Giugliano, D
背景肥胖是心血管疾病的独立危险因素，这可能是由脂肪组织促炎细胞因子分泌增加介导的。目的确定旨在持续减轻体重的生活方式改变计划对全身血管炎症和胰岛素抵抗标志物的影响。1999年2月至2002年2月在意大利的一所大学医院进行的盲法试验。（体重指数大于或等于30）年龄20至46岁，无糖尿病、高血压、干预措施随机分配到干预组的60名妇女接受了关于如何通过低能量地中海式饮食和增加体力活动来实现体重减轻10%或更多的详细建议。对照组（n = 60）给予健康饮食选择和运动的一般信息。主要结果测量血脂和葡萄糖摄入量，血压，胰岛素敏感性稳态模型评估，以及循环中白细胞介素6（IL-6）、白细胞介素18（IL-18）、C反应蛋白（CRP）和脂联素水平。结果2年后，干预组的女性摄入更多富含复合碳水化合物的食物（9%校正差异; P
Context Obesity is an independent risk factor for cardiovascular disease, which may be mediated by increased secretion of proinflammatory cytokines by adipose tissue.Objective To determine the effect of a program of changes in lifestyle designed to obtain a sustained reduction of body weight on markers of systemic vascular inflammation and insulin resistance.Design and Setting Randomized single-blind trial conducted from February 1999 to February 2002 at a university hospital in Italy.Patients One hundred twenty premenopausal obese women (body mass index greater than or equal to30) aged 20 to 46 years without diabetes, hypertension, or hyperlipidemia.Interventions The 60 women randomly assigned to the intervention group received detailed advice about how to achieve a reduction of weight of 10% or more through a low-energy Mediterranean-style diet and increased physical activity. The control group (n = 60) was given general information about healthy food choices and exercise.Main Outcome Measures Lipid and glucose intake; blood pressure; homeostatic model assessment of insulin sensitivity; and circulating levels of interleukin 6 (IL-6), interleukin 18 (IL-18), C-reactive protein (CRP), and adiponectin.Results After 2 years, women in the intervention group consumed more foods rich in complex carbohydrates (9% corrected difference; P