New Cytotoxic and Antibacterial Compounds Isolated from the Sea Hare, Aplysia kurodai
New Cytotoxic and Antibacterial Compounds Isolated from the Sea Hare, Aplysia kurodai
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DOI：
10.3390/md302022
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发表时间：
2005-04
期刊：
影响因子：
5.4
通讯作者：
S. Tsukamoto;Y. Yamashita;T. Ohta
中科院分区：
文献类型：
--
作者：
S. Tsukamoto;Y. Yamashita;T. Ohta
海兔提取物对HeLa细胞具有细胞毒作用，对金黄色葡萄球菌具有抗菌活性。生物活性分离纯化得到4个活性化合物，经光谱分析鉴定为月桂醇、月桂醇乙酸酯、脱溴月桂醇和脱溴月桂醇醋酸酯。虽然乙酸酯以前是从月桂醇和脱溴月桂醇中提取出来的，但这是首次从天然来源中分离出乙酸酯。
The extract of the sea hare, Aplysia kurodai, showed cytotoxicity against HeLa cells and antibacterial activity against Staphylococcus aureus. Bioassay-guided purification afforded four active compounds, which were identified to be laurinterol, laurinterol acetate, debromolaurinterol, and debromolaurinterol acetate by spectroscopic analysis. Although the acetates were derived from laurinterol and debromolaurinterol before, this is the first isolation of the acetates from natural sources.