Human Cord Blood Transplantation in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage: Functional Outcome Related to Neuroprotection in the Striatum
Human Cord Blood Transplantation in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage: Functional Outcome Related to Neuroprotection in the Striatum
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DOI：
10.1089/scd.2009.0049
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发表时间：
2010-03-01
影响因子：
4
通讯作者：
Mendez-Otero, Rosalia
中科院分区：
文献类型：
--
作者：
Pimentel-Coelho, Pedro M.;Magalhaes, Elizabeth S.;Mendez-Otero, Rosalia
人脐带血单核细胞 (HUCB) 已被证明对不同的中枢神经系统 (CNS) 损伤模型（包括中风）具有治疗作用。我们评估了 HUCB 对新生儿缺氧缺血 (HI) 脑损伤 Rice-Vannucci 模型的 P7 大鼠的可能治疗潜力。我们的结果表明，HI 损伤后 3 小时腹腔内移植 HUCB，在损伤后第一周的两项发育性感觉运动反射中产生了更好的表现。我们还显示出对纹状体的神经保护作用，以及治疗动物大脑皮层中活化小胶质细胞数量的减少。我们认为 HUCB 移植可能会挽救新生儿 HI 损伤后纹状体神经元免于细胞死亡，从而实现更好的功能恢复。
Human umbilical cord blood mononuclear cells (HUCB) have been shown to have a therapeutic role in different models of central nervous system (CNS) damage, including stroke. We evaluated the possible therapeutic potential of HUCB in P7 rats submitted to the Rice-Vannucci model of neonatal hypoxic-ischemic (HI) brain damage. Our results demonstrated that intraperitoneal transplantation of HUCB, 3 h after the HI insult, resulted in better performance in two developmental sensorimotor reflexes, in the first week after the injury. We also showed a neuroprotective effect in the striatum, and a decrease in the number of activated microglial cells in the cerebral cortex of treated animals. We suggest that HUCB transplantation might rescue striatal neurons from cell death after a neonatal HI injury resulting in better functional recovery.