Role of gamma interferon in controlling murine chlamydial genital tract infection
Role of gamma interferon in controlling murine chlamydial genital tract infection
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DOI：
10.1128/iai.67.10.5518-5521.1999
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发表时间：
1999-10-01
影响因子：
3.1
通讯作者：
Lyons, JM
中科院分区：
文献类型：
--
作者：
Ito, JI;Lyons, JM
早期的研究尚未显示γ干扰素（IFN-γ）在早期清除小鼠雌性生殖道衣原体感染中的重要作用。在一个模型中，使用人生殖道沙眼衣原体分离IFN-γ和IFN-γ受体敲除小鼠，我们能够证明一个主要的作用，IFN-γ在整个感染过程中介导的感染控制。
Earlier investigations have not shown an important role for gamma interferon (IFN-gamma) in the early clearance of chlamydial infection from the murine female genital tract. In a model using a human genital isolate of Chlamydia trachomatis in IFN-gamma and IFN-gamma receptor knockout mice, we were able to demonstrate a major role for IFN-gamma in mediating control of infection throughout the course of infection.