Pharmacological and biochemical actions of simple coumarins: Natural products with therapeutic potential
Pharmacological and biochemical actions of simple coumarins: Natural products with therapeutic potential
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DOI：
10.1016/0306-3623(95)02112-4
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发表时间：
1996-06-01
期刊：
影响因子：
--
通讯作者：
Paya, M
中科院分区：
文献类型：
--
作者：
Hoult, JRS;Paya, M
1.已从天然来源，特别是绿色植物中鉴定出1300多种香豆素。简单香豆素的药理、生化性质和治疗应用取决于取代模式。基于香豆素核的更复杂的相关化合物包括双香豆素/华法林抗凝剂、黄曲霉毒素和补骨脂素(光敏剂)。香豆素本身(1，2-苯并吡喃酮)长期以来在缓发长期减轻人类淋巴水肿方面已经确立了疗效，最近针对象皮病和乳房切除术后手臂肿胀的双盲试验证实了这一点。作用机制尚不清楚，但可能涉及巨噬细胞诱导的水肿蛋白的蛋白分解。然而，香豆素在人体内的绝对生物利用度较低(
1. More than 1300 coumarins have been identified from natural sources, especially green plants. The pharmacological and biochemical properties and therapeutic applications of simple coumarins depend upon the pattern of substitution. More complex related compounds based on the coumarin nucleus include the dicoumarol/warfarin anticoagulants, aflatoxins and the psoralens (photosensitizing agents).2. Coumarin itself (1,2-benzopyrone) has long established efficacy in slow onset long-term reduction of lymphoedema in man, as confirmed in recent double-blind trials against elephantiasis and postmastectomy swelling of the arm. The mechanism of action is uncertain, but may involve macrophage induced proteolysis of oedema protein. However, coumarin has low absolute bioavailability in man (