The novel platelet activation receptor CLEC-2
The novel platelet activation receptor CLEC-2
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DOI：
10.3109/09537104.2011.556274
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发表时间：
2011-08
期刊：
影响因子：
3.3
通讯作者：
K. Suzuki-Inoue;O. Inoue;Y. Ozaki
中科院分区：
文献类型：
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作者：
K. Suzuki-Inoue;O. Inoue;Y. Ozaki
C型凝集素样受体2（CLEC-2）首先从C型凝集素样受体的生物信息学筛选中鉴定。然而，多年来它的功能及其配体都没有得到阐明。在2006年，我们报道了该受体在血小板表面表达，并作为蛇毒红细胞素的受体，其有效地刺激血小板聚集。从那时起，CLEC-2已被深入研究，其内源性/外源性配体和几种生理/病理作用已被阐明。本文就CLEC-2的结构、分布、信号转导机制和功能进行综述。
The c-type lectin-like receptor 2 (CLEC-2) was first identified from a bio-informatic screen for c-type lectin-like receptors. However, neither its function nor its ligand(s) had been elucidated for several years. In 2006, we reported that the receptor is expressed on the surface of platelets and serves as a receptor for the snake venom rhodocytin, which potently stimulates platelet aggregation. Since then CLEC-2 has been intensively investigated, and its endogenous/exogenous ligands and several physiological/pathological roles have been clarified. In this article and its accompanying poster, we outline the structure, distribution, signal transduction mechanism and functions of CLEC-2.