Alcohol inhibits suckling-induced oxytocin release in the lactating rat.
Alcohol inhibits suckling-induced oxytocin release in the lactating rat.
复制标题
酒精抑制哺乳大鼠哺乳诱导的催产素释放。
DOI：
10.1016/s0741-8329(99)00017-8
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Subramanian,MG
中科院分区：
文献类型：
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作者：
Subramanian,MG
在初产哺乳大鼠中，观察了酒精灌胃后催产素的释放情况。哺乳的大鼠在第二天产仔8只，在哺乳期的第6-8天植入心房导管。4天后，分别灌胃0.0g/kgbw、1.0g/kgbw和2.0g/kgbw的酒精，并维持初始剂量后的血液酒精水平4h。在酒精灌输完成后，取基线血样，将幼崽送回母犬，并在哺乳开始后5、10、30和60分钟采集额外的样本。用放射免疫法测定血浆催产素水平。测定哺乳潜伏期和哺乳60min内的乳汁消耗量。酒精在所有时间点均可抑制哺乳诱导的催产素释放。不同组之间的哺乳潜伏期是相似的。饮酒组幼鼠在哺乳60min内的乳汁消耗量较低。本研究的数据表明，给哺乳期大鼠急性酒精灌胃可抑制哺乳诱导的催产素释放，导致乳汁分泌减少。
Oxytocin release in response to suckling was examined in primiparous lactating rats following alcohol administration. Lactating rats, with litters adjusted to eight pups on day 2, were implanted with an atrial catheter between days 6 to 8 of lactation. Four days later, alcohol in doses 0.0, 1.0, or 2.0 g/kg BW was infused, and blood alcohol levels achieved following infusion of initial doses were maintained for 4 h. On the day of alcohol infusion, pups were separated from the dams at 8:00 a.m. Following completion of alcohol infusion, a baseline blood sample was obtained, pups were returned to the dams, and additional samples were obtained 5, 10, 30, and 60 min after suckling started. Oxytocin levels in plasma were determined by radioimmunoassay. Suckling latencies and milk consumption during the 60 min of suckling were determined. Alcohol administration inhibited suckling-induced oxytocin release across all time points. Suckling latencies among groups were comparable. Milk consumption by pups during the 60 min of suckling was lower for the alcohol administered groups. The data from the present study demonstrate that acute alcohol administration to lactating rats inhibits suckling-induced oxytocin release resulting in reduction of milk secretion.