Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases.
Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases.
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DOI：
10.1016/j.jaci.2013.04.039
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发表时间：
2013-07
影响因子：
14.2
通讯作者：
Rothenberg, Marc E.
中科院分区：
文献类型：
--
作者：
Lu, Thomas X.;Rothenberg, Marc E.
关键词：
过敏性炎症伴随着启动、维持和传播免疫应答和组织重塑的无数基因和蛋白质的协调表达。MicroRNA（miRNAs）是一类短的单链RNA分子，其在转录后沉默基因表达，并且已经显示出微调基因转录网络，因为单个miRNAs可以靶向数百个基因。[7]相当多的注意力集中在miRNA在调节稳态免疫结构和获得性免疫中的关键作用上。最近的研究已经确定了多种过敏性炎症性疾病，包括哮喘，嗜酸性食管炎，过敏性鼻炎和特应性皮炎的miRNA谱。已经发现特异性miRNA在调节过敏性炎症中的关键致病机制中具有关键作用，包括适应性免疫应答的极化和T细胞的活化（例如miR-21和miR-146）、嗜酸性粒细胞发育的调节（例如miR-21和miR-223）以及白细胞介素（IL）-13驱动的上皮应答的调节（例如miR-375）。本文就miRNAs在变应性炎症中的表达和功能、作为疾病生物标志物的作用以及未来研究和临床应用的前景进行综述。
Allergic inflammation is accompanied by the coordinated expression of a myriad of genes and proteins that initiate, sustain, and propagate immune responses and tissue remodeling. MicroRNAs (miRNAs) are a class of short single-stranded RNA molecules that post-transcriptionally silence gene expression and have been shown to fine-tune gene transcriptional networks as single miRNAs can target hundreds of genes. 7 Considerable attention has focused on the key role of miRNAs in regulating homeostatic immune architecture and acquired immunity. Recent studies have identified miRNA profiles in multiple allergic inflammatory diseases including asthma, eosinophilic esophagitis, allergic rhinitis, and atopic dermatitis. Specific miRNAs have been found to have critical roles in regulating key pathogenic mechanisms in allergic inflammation including polarization of adaptive immune responses and activation of T cells (e.g. miR-21 and miR-146), regulation of eosinophil development (e.g. miR-21 and miR-223), and modulation of interleukin (IL)-13-driven epithelial responses (e.g. miR-375). This review discusses recent advances in our understanding of the expression and function of miRNAs in allergic inflammation, their role as disease biomarkers, and perspectives for future investigation and clinical utility.
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影响因子：
3.7
作者：
Garbacki N;Di Valentin E;Huynh-Thu VA;Geurts P;Irrthum A;Crahay C;Arnould T;Deroanne C;Piette J;Cataldo D;Colige A
通讯作者：
Colige A
影响因子：
3.7
作者：
Gallo A;Tandon M;Alevizos I;Illei GG
通讯作者：
Illei GG
DOI：
10.1073/pnas.0607863103
发表时间：
2006-10-31
影响因子：
11.1
作者：
Fulkerson, Patricia C.;Fischetti, Christine A.;Rothenberg, Marc E.
通讯作者：
Rothenberg, Marc E.
DOI：
10.1165/rcmb.2004-0243oc
发表时间：
2005-02-01
影响因子：
6.4
作者：
Deshpande, DA;White, TA;Kannan, MS
通讯作者：
Kannan, MS
DOI：
10.1165/rcmb.2005-0474oc
发表时间：
2006-09-01
影响因子：
6.4
作者：
Fulkerson, Patricia C.;Fischetti, Christine A.;Rothenberg, Marc E.
通讯作者：
Rothenberg, Marc E.