The DrugAge database of aging-related drugs.
The DrugAge database of aging-related drugs.
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DOI：
10.1111/acel.12585
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发表时间：
2017-06
期刊：
影响因子：
7.8
通讯作者：
de Magalhães JP
中科院分区：
文献类型：
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作者：
Barardo D;Thornton D;Thoppil H;Walsh M;Sharifi S;Ferreira S;Anžič A;Fernandes M;Monteiro P;Grum T;Cordeiro R;De-Souza EA;Budovsky A;Araujo N;Gruber J;Petrascheck M;Fraifeld VE;Zhavoronkov A;Moskalev A;de Magalhães JP
老龄化是一个全球性的重大医学挑战。毫不奇怪，识别延长模式生物寿命的药物和化合物是一个不断发展的研究领域。在这里，我们提出了DrugAge (http://genomics.senescence.info/drugs/)，一个精心策划的延长寿命的药物和化合物数据库。在撰写本文时，DrugAge包含来自27种模式生物（包括蠕虫、苍蝇、酵母和小鼠）研究的418种不同化合物的1316个条目。数据由324份出版物手工整理。利用药物-基因相互作用数据，我们还对延长寿命药物的靶点进行了功能富集分析。丰富的术语包括与谷胱甘肽和抗氧化活性、离子转运和代谢过程有关的各种功能类别。此外，我们发现延长寿命药物的靶点与已知的衰老相关基因之间存在适度但显著的重叠，这表明在长寿研究中，一些（但不是大多数）衰老相关途径已成为药理学上的靶点。DrugAge是科学界在线免费提供的，将成为生物学家的重要资源。
Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics.senescence.info/drugs/), a curated database of lifespan‐extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug–gene interaction data, we also performed a functional enrichment analysis of targets of lifespan‐extending drugs. Enriched terms include various functional categories related to glutathione and antioxidant activity, ion transport and metabolic processes. In addition, we found a modest but significant overlap between targets of lifespan‐extending drugs and known aging‐related genes, suggesting that some but not most aging‐related pathways have been targeted pharmacologically in longevity studies. DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists.