Atlases of cognition with large-scale human brain mapping
Atlases of cognition with large-scale human brain mapping
复制标题
大规模人脑绘图的认知图谱
DOI：
10.1371/journal.pcbi.1006565
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发表时间：
2018
影响因子：
4.3
通讯作者：
B. Thirion
中科院分区：
文献类型：
--
作者：
G. Varoquaux;Y. Schwartz;R. Poldrack;Baptiste Gauthier;D. Bzdok;J. Poline;B. Thirion
为了描绘精神功能的神经基础，认知神经成像依赖于受控的心理操作，这些操作涉及与特定认知过程相关的大脑系统。为了建立大脑认知功能的全面图谱，它必须为许多不同的认知过程汇编地图，这些过程往往会引起重叠的激活模式。这样的数据汇总面临着截然不同的目标：一方面在截然不同的认知实验中找到对应关系，另一方面准确描述任何给定大脑区域的功能。在这里，我们介绍了一个新的分析框架，它解决了这些困难，从而能够生成认知功能的脑地图集。该方法利用认知概念的本体和多标签大脑解码来映射这些概念的神经基础。我们通过基于30个不同的功能神经成像研究，总计196个不同的实验条件，建立了一个功能脑组织图谱来演示该方法。与传统的大脑图谱不同，这一功能图谱支持强大的反向推理：根据图谱所描绘区域的大脑活动预测心理过程。为了证明这种反向推理确实受到相应概念的支配，而不是实验设计的特殊性，我们证明了它可以准确地解码在新任务中招募的认知概念。这些结果表明，聚合独立的任务-功能磁共振研究可以提供更精确的大脑和认知之间选择性联系的全球图谱。
To map the neural substrate of mental function, cognitive neuroimaging relies on controlled psychological manipulations that engage brain systems associated with specific cognitive processes. In order to build comprehensive atlases of cognitive function in the brain, it must assemble maps for many different cognitive processes, which often evoke overlapping patterns of activation. Such data aggregation faces contrasting goals: on the one hand finding correspondences across vastly different cognitive experiments, while on the other hand precisely describing the function of any given brain region. Here we introduce a new analysis framework that tackles these difficulties and thereby enables the generation of brain atlases for cognitive function. The approach leverages ontologies of cognitive concepts and multi-label brain decoding to map the neural substrate of these concepts. We demonstrate the approach by building an atlas of functional brain organization based on 30 diverse functional neuroimaging studies, totaling 196 different experimental conditions. Unlike conventional brain mapping, this functional atlas supports robust reverse inference: predicting the mental processes from brain activity in the regions delineated by the atlas. To establish that this reverse inference is indeed governed by the corresponding concepts, and not idiosyncrasies of experimental designs, we show that it can accurately decode the cognitive concepts recruited in new tasks. These results demonstrate that aggregating independent task-fMRI studies can provide a more precise global atlas of selective associations between brain and cognition.
DOI：
10.1056/nejmoa1204471
发表时间：
2013-04-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Wager TD;Atlas LY;Lindquist MA;Roy M;Woo CW;Kross E
通讯作者：
Kross E