Interferon alpha-2a treatment for refractory Behcet uveitis in Korean patients.
Interferon alpha-2a treatment for refractory Behcet uveitis in Korean patients.
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DOI：
10.1186/s12886-018-0719-0
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发表时间：
2018-02-20
影响因子：
2
通讯作者：
Lee SC
中科院分区：
文献类型：
--
作者：
Lee JH;Lee CS;Lee SC
To evaluate therapeutic outcomes of interferon alpha-2a (IFNα2a) treatment in patients with Behcet’s disease who were refractory to immunosuppressive agents. This retrospective case series reviewed the medical records of 5 patients with refractory Behcet uveitis from January 2011 to February 2017. IFNα2a was administered at a dose of 3 million IU 3 times per week. Clinical response, relapse rate, and change of visual acuity were evaluated. The mean age of patients was 39.60 ± 9.21 years, and the median treatment duration was 6 months. Four of the 5 patients (80%) presented with responses to IFNα2a without any uveitis attack during the treatment period. The mean number of uveitis attacks/year per patient during the treatment was 0.40 ± 0.89. The mean log of the Minimum Angle of Resolution visual acuity improved from 1.44 ± 0.38 at baseline to 1.02 ± 0.58 at the final follow up. IFNα2a is an effective therapy for Behcet uveitis refractory to conventional immunosuppressants in Korean patients.
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影响因子：
4.1
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通讯作者：
Stübiger, N
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5.5
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2.3
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