Drusen are associated with local and distant disruptions to human retinal pigment epithelium cells
Drusen are associated with local and distant disruptions to human retinal pigment epithelium cells
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DOI：
10.1016/j.exer.2008.09.021
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发表时间：
2009-03-01
影响因子：
3.4
通讯作者：
Jeffery, Glen
中科院分区：
文献类型：
--
作者：
Al-Hussaini, Heba;Schneiders, Matthew;Jeffery, Glen
玻璃体是在视网膜色素上皮(RPE)和布鲁赫膜(BM)之间形成的细胞外沉积物。大量和/或融合的玻璃体是老年性黄斑变性(AMD)的重要危险因素。在这里，使用整装的人RPE制剂，我们显示了RPE细胞的形态变化与玻璃体形成有关。这些变化包括细胞大小的增加和分布规律性的扭曲。此外，尽管双核现象在人类RPE中相对罕见，但与单个DRUSE相关的双核RPE细胞的数量显著增加。令人惊讶的是，这些变化中的许多都是在距离干酪400亩的地方发现的。(C)2008爱思唯尔有限公司。保留所有权利。
Drusen are extra-cellular deposits that form between the retinal pigment epithelium (RPE) and Bruch's membrane (BM). Numerous and/or confluent drusen are a significant risk factor for age-related macular degeneration (AMD). Here, using whole mounted human RPE preparation we show that RPE cell morphology changes in association with drusen. These changes included an increase in cell size and distortion in the regularity of their distribution. Further, although binucleation is relatively rare in human RPE, there was a marked increase in the number of binucleated RPE cell associated with individual druse. Surprisingly many of these changes were found at distances up to 400 mu m from drusen. (C) 2008 Elsevier Ltd. All rights reserved.