Bronsted Acid-Catalyzed General Petasis Allylation and Isoprenylation of Unactivated Ketones
Bronsted Acid-Catalyzed General Petasis Allylation and Isoprenylation of Unactivated Ketones
复制标题
布朗斯台德酸催化未活化酮的通用 Petasis 烯丙基化和异戊二烯化
DOI：
10.1002/chem.202001594
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Huang Yi-Yong
中科院分区：
文献类型：
--
作者：
Zhou Yang;Zhao Zhen-Ni;Zhang Yu-Long;Liu Jun;Yuan Quan;Schneider Uwe;Huang Yi-Yong
以邻羟基苯胺和相应的片呐醇基硼酸酯为原料，研究了Brnsted酸催化的未活化酮的普通Petsis烯丙基化和异戊二烯基化反应。这一可靠的方法提供了以高产率获得各种季铵高烯丙基胺和二烯基胺的途径，被证明适用于克规模的合成，并允许合成具有潜在生物活性的季铵高烯丙基氨基二醇。
Brønsted acid‐catalyzed general Petasis allylation and isoprenylation of unactivated ketones were developed by usingo‐hydroxyaniline and the corresponding pinacolyl boronic esters. This robust methodology provided access to a broad variety of quaternary homoallylic amines and dienyl amines in high yields, proved to be applicable to a gram‐scale synthesis, and allowed the synthesis of a potentially bioactive quaternary homoallylic aminodiol.