INCIDENCE OF SYSTEMIC LUPUS-ERYTHEMATOSUS - RACE AND GENDER DIFFERENCES
INCIDENCE OF SYSTEMIC LUPUS-ERYTHEMATOSUS - RACE AND GENDER DIFFERENCES
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DOI：
10.1002/art.1780380914
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发表时间：
1995-09-01
影响因子：
--
通讯作者：
KWOH, CK
中科院分区：
文献类型：
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作者：
MCCARTY, DJ;MANZI, S;KWOH, CK
目的，检查系统性红斑狼疮 (SLE) 发病率的种族差异。方法，通过医疗记录审查（匹兹堡大学狼疮数据库、风湿病学家和医院）、使用捕获-再捕获方法，使用宾夕法尼亚州阿勒格尼县基于人群的 SLE 患者登记系统，从 3 个来源识别 1985 年 1 月 1 日至 1990 年 12 月 31 日期间诊断的 SLE 病例。使用对数线性模型来估计病例发现水平并计算 95% 置信区间 (CI)，计算每 100,000 人的发病率。结果，总共确定了 191 例明确的 SLE 病例和 78 例可能的 SLE 病例，总体年发病率分别为 2.4 (95% CI 2,1-2,8) 和 1.0 (95% CI 0.8-1,3)，确诊 SLE 的粗发病率为白人男性 0.4、白人女性 3.5、非裔美国男性 0.7、非裔美国女性 9.2。在研究期间，确诊 SLE 的年发病率保持相当稳定，与白人女性相比，确诊 SLE 的非洲裔美国女性诊断时的平均年龄更年轻（P < 0.05），因为总体确定率较高（85%；95% CI） 78-92%），确定性 SLE 的确定校正发病率为 2.8（95% CI 2.6-3.2），与粗略发病率相似。结论，我们的发病率明确证实了之前关于女性与男性相比、非裔美国人与白人相比 SLE 发病率过高的报道。我们使用捕获-再捕获方法来提高 SLE 发病率的准确性，我们提倡使用它们来促进研究之间的比较。
Objective, To examine racial differences in the incidence of systemic lupus erythematosus (SLE).Methods, A population-based registry of SLE patients in Allegheny County, Pennsylvania, was used to identify incident cases of SLE diagnosed between January 1, 1985 and December 31, 1990, from 3 sources, by medical record review (University of Pittsburgh Lupus Databank, rheumatologists, and hospitals), Capture-recapture methods using log-linear models were used to estimate the level of case-finding and to calculate 95% confidence intervals (CI), Incidence rates were calculated per 100,000 population.Results, A total of 191 definite and 78 probable incident cases of SLE were identified, and the overall annual incidence rates were 2.4 (95% CI 2,1-2,8) and 1.0 (95% CI 0.8-1,3), respectively, The crude incidence rates of definite SLE were 0.4 for white males, 3.5 for white females, 0.7 for African-American males, and 9.2 for African-American females, The annual incidence rates of definite SLE remained fairly constant over the study interval, African-American females with definite SLE had a younger mean age at diagnosis compared with white females (P < 0.05), Since the overall ascertainment rate was high (85%; 95% CI 78-92%), the ascertainment-corrected incidence rate for definite SLE, 2.8 (95% CI 2.6-3.2), was similar to the crude rate.Conclusion, Our rates clearly confirm previous reports of an excess incidence of SLE among females compared with males and among African-Americans compared with whites, We have used capture-recapture methods to improve the accuracy of SLE incidence rates, and we advocate their use to facilitate comparisons across studies.